(Q40661872)

22 September 2017

title

A myristoyl/phosphotyrosine switch regulates c-Abl (English)

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22 September 2017

7

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22 September 2017

5

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Oliver Hantschel

1

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Sebastian Guettler

object named as

Sebastian Guettler

3

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author name string

Bhushan Nagar

2

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22 September 2017

Jana Kretzschmar

4

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22 September 2017

John Kuriyan

6

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22 September 2017

language of work or name

English

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publication date

1 March 2003

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22 September 2017

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22 September 2017

volume

112

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22 September 2017

issue

6

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22 September 2017

page(s)

845-857

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Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

22 September 2017

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An intramolecular SH3-domain interaction regulates c-Abl activity

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A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.

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Oncogenic kinase signalling

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c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

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Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain

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Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation

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Domain movements in protein kinases

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Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line

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Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase.

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl

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c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis

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The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.

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Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis

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Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src.

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Structural analysis of receptor tyrosine kinases

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Protein tyrosine kinases: autoregulation and small-molecule inhibition

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Protein tyrosine kinase structure and function

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The conformational plasticity of protein kinases

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Essential roles for the Abl and Arg tyrosine kinases in neurulation

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The protein kinase complement of the human genome

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7 January 2021

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo

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A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

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7 January 2021

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

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7 January 2021

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

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7 January 2021

Structural basis for the autoinhibition of c-Abl tyrosine kinase

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7 January 2021

The Abl family kinases: mechanisms of regulation and signaling

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7 January 2021

c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF

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7 January 2021

Autoinhibition of c-Abl

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7 January 2021

Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand

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7 January 2021

Differential expression of type-specific c-abl mRNAs in mouse tissues and cell lines

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7 January 2021

Myristylation and palmitylation of Src family members: the fats of the matter

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7 January 2021

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

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7 January 2021

Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop

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7 January 2021

Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src

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7 January 2021

Disabling Abl-perspectives on Abl kinase regulation and cancer therapeutics

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7 January 2021

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

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7 January 2021

Cell signaling by receptor tyrosine kinases

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7 January 2021

Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations

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7 January 2021

Crystal structure of the Src family tyrosine kinase Hck

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7 January 2021

Structure-function relationships in Src family and related protein tyrosine kinases

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7 January 2021

Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

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7 January 2021

Protein myristoylation in protein-lipid and protein-protein interactions

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7 January 2021

Protein kinase inhibition: natural and synthetic variations on a theme

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7 January 2021

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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7 January 2021

Cycling, stressed-out and nervous: cellular functions of c-Abl

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7 January 2021

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity

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7 January 2021

The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

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7 January 2021

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

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7 January 2021

Three-dimensional structure of the tyrosine kinase c-Src

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7 January 2021

Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor

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7 January 2021

Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

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7 January 2021

Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor

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7 January 2021

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

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7 January 2021

The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19

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7 January 2021

10.1016/S0092-8674(03)00191-0

Identifiers

DOI

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22 September 2017

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