(Q40627982)

English

Tyrosine Kinase p56 Regulates Cell Motility and Nuclear Factor κB-mediated Secretion of Urokinase Type Plasminogen Activator through Tyrosine Phosphorylation of IκBα following Hypoxia/Reoxygenation

scientific article published on October 8, 2003

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Europe PubMed Central

PubMed publication ID

22 September 2017

Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Tyrosine Kinase p56 Regulates Cell Motility and Nuclear Factor κB-mediated Secretion of Urokinase Type Plasminogen Activator through Tyrosine Phosphorylation of IκBα following Hypoxia/Reoxygenation (English)

1 reference

10.1074/JBC.M308941200

https://api.crossref.org/works/10.1074/JBC.M308941200

19 March 2024

phosphorylation

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based on heuristic

inferred from title

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10.1074/JBC.M308941200

https://api.crossref.org/works/10.1074/JBC.M308941200

19 March 2024

1 reference

10.1074/JBC.M308941200

https://api.crossref.org/works/10.1074/JBC.M308941200

19 March 2024

2

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Gopal C Kundu

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Europe PubMed Central

PubMed publication ID

22 September 2017

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Ganapati H. Mahabeleshwar

1

0000-0001-9332-6664

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534291

19 March 2024

Gopal C. Kundu

2

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19 March 2024

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8 October 2003

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22 September 2017

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http://www.jbc.org/article/S0021925820752725/pdf

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534291

19 March 2024

https://api.elsevier.com/content/article/PII:S0021925820752725?httpAccept=text/xml

1 reference

10.1074/JBC.M308941200

https://api.crossref.org/works/10.1074/JBC.M308941200

19 March 2024

https://api.elsevier.com/content/article/PII:S0021925820752725?httpAccept=text/plain

1 reference

10.1074/JBC.M308941200

https://api.crossref.org/works/10.1074/JBC.M308941200

19 March 2024

https://syndication.highwire.org/content/doi/10.1074/jbc.M308941200

1 reference

10.1074/JBC.M308941200

https://api.crossref.org/works/10.1074/JBC.M308941200

19 March 2024

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

278

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

52

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

52598-52612

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

The plasminogen activation system in tumor growth, invasion, and metastasis

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Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations

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Microenvironment-induced cancer metastasis

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Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation

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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

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Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.

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The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes

1 reference

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1 reference

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Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line

1 reference

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Profound block in thymocyte development in mice lacking p56lck

1 reference

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Functional dissection of the lck proximal promoter

1 reference

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Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts

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Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck)

1 reference

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21 January 2018

Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells

1 reference

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21 January 2018

Correlation between phosphorylation and kinase activity of a tyrosine protein kinase: p56lck

1 reference

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21 January 2018

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation

1 reference

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Stimulation of phosphorylation of Tyr394 by hydrogen peroxide reactivates biologically inactive, non-membrane-bound forms of Lck.

1 reference

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Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

1 reference

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Missing pieces in the NF-kappaB puzzle

1 reference

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I kappa B: a specific inhibitor of the NF-kappa B transcription factor

1 reference

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The NF-kappa B and I kappa B proteins: new discoveries and insights

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

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Alterations in the local myocardial motion pattern in patients suffering from pressure overload due to aortic stenosis

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Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases

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Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha.

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Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation.

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Osteopontin stimulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells

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Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells

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Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways

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Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells

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Thymic tumorigenesis induced by overexpression of p56lck

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Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.

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Cancer Research

3

49

6449

author name string

Vaupel

publication date

1989

1 reference

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Current status of knowledge and critical issues in tumor oxygenation. Results from 25 years research in tumor pathophysiology

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A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy

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Cancer Research

7

59

4525

author name string

Hockel

publication date

1999

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Cancer Research

11

60

883

author name string

Koong

publication date

2000

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The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity

23

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Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

37

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Identifiers

10.1074/JBC.M308941200

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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