(Q40217824)

18 September 2017

title

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. (English)

1 reference

18 September 2017

Mikhail V Semenov

1

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18 September 2017

Xi He

series ordinal

2

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18 September 2017

language of work or name

English

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publication date

19 October 2006

1 reference

Journal of Biological Chemistry

18 September 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

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18 September 2017

volume

281

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18 September 2017

issue

50

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18 September 2017

page(s)

38276-38284

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A Wnt canon orchestrating osteoblastogenesis

18 September 2017

cites work

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21 January 2018

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21 January 2018

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The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts

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21 January 2018

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High bone density due to a mutation in LDL-receptor-related protein 5

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Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

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High bone mass in mice expressing a mutant LRP5 gene

21 January 2018

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Bone biomechanical properties in LRP5 mutant mice

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

21 January 2018

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

21 January 2018

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

21 January 2018

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

21 January 2018

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

21 January 2018

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Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation

21 January 2018

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Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity

21 January 2018

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21 January 2018

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Wise, a context-dependent activator and inhibitor of Wnt signalling

21 January 2018

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Bone mineral density in sclerosteosis; affected individuals and gene carriers

21 January 2018

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M609509200

21 January 2018

Identifiers

DOI

10.1074/JBC.M609509200

1 reference

18 September 2017

1 reference