(Q40132452)

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Increased sensitivity of radiated murine cervical cancer tumors to E7 subunit vaccine-driven CTL-mediated killing induces synergistic anti-tumor activity.

scientific article published on May 2007

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Europe PubMed Central

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30 December 2019

Increased sensitivity of radiated murine cervical cancer tumors to E7 subunit vaccine-driven CTL-mediated killing induces synergistic anti-tumor activity (English)

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Europe PubMed Central

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30 December 2019

cervix uterine cancer

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inferred from title

4

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30 December 2019

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Gi Won Ye

1

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30 December 2019

Jae-Bok Park

2

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30 December 2019

Young-Ja Park

3

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30 December 2019

Jeong-Im Sin

5

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30 December 2019

publication date

1 May 2007

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30 December 2019

Molecular Therapy

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30 December 2019

15

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30 December 2019

8

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30 December 2019

1564-1570

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30 December 2019

Human papillomaviruses in the pathogenesis of anogenital cancer

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

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Association of human papillomavirus types 16 and 18 E6 proteins with p53.

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The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

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Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6.

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Both antigen optimization and lysosomal targeting are required for enhanced anti-tumour protective immunity in a human papillomavirus E7-expressing animal tumour model

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Liposome-polycation-DNA (LPD) particle as a carrier and adjuvant for protein-based vaccines: therapeutic effect against cervical cancer

1 reference

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7 January 2021

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CpG-ODN-stimulated dendritic cells act as a potent adjuvant for E7 protein delivery to induce antigen-specific antitumour immunity in a HPV 16 E7-associated animal tumour model

1 reference

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7 January 2021

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Regression of established human papillomavirus type 16 (HPV-16) immortalized tumors in vivo by vaccinia viruses expressing different forms of HPV-16 E7 correlates with enhanced CD8(+) T-cell responses that home to the tumor site

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7 January 2021

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A Therapy Modality Using Recombinant IL-12 Adenovirus plus E7 Protein in a Human Papillomavirus 16 E6/E7-Associated Cervical Cancer Animal Model

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7 January 2021

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An adenoviral vector cancer vaccine that delivers a tumor-associated antigen/CD40-ligand fusion protein to dendritic cells

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Multistep process through which adenoviral vector vaccine overcomes anergy to tumor-associated antigens

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7 January 2021

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A novel mucosal vaccine based on live Lactococci expressing E7 antigen and IL-12 induces systemic and mucosal immune responses and protects mice against human papillomavirus type 16-induced tumors

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7 January 2021

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Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells

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7 January 2021

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Therapeutic vaccination with papillomavirus E6 and E7 long peptides results in the control of both established virus-induced lesions and latently infected sites in a pre-clinical cottontail rabbit papillomavirus model

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7 January 2021

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Antitumor therapeutic effects of e7 subunit and DNA vaccines in an animal cervical cancer model: antitumor efficacy of e7 therapeutic vaccines is dependent on tumor sizes, vaccine doses, and vaccine delivery routes

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7 January 2021

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Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis.

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7 January 2021

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Cytotoxic T lymphocyte responses to E6 and E7 proteins of human papillomavirus type 16: relationship to cervical intraepithelial neoplasia

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Persistence of human papillomavirus type 16 infection is associated with lack of cytotoxic T lymphocyte response to the E6 antigens

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Inverse correlation of cellular immune responses specific to synthetic peptides from the E6 and E7 oncoproteins of HPV-16 with recurrence of cervical intraepithelial neoplasia in a cross-sectional study

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7 January 2021

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Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

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Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract

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CpG motifs in bacterial DNA trigger direct B-cell activation

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APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells

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TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).

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Therapeutic synergy of human papillomavirus E7 subunit vaccines plus cisplatin in an animal tumor model: causal involvement of increased sensitivity of cisplatin-treated tumors to CTL-mediated killing in therapeutic synergy

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Antitumor immune response induced by i.t. injection of vector-activated dendritic cells and chemotherapy suppresses metastatic breast cancer

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Human papillomavirus vaccines for the treatment of cervical cancer

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Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy

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External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing

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Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes

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Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

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Identifiers

10.1038/SJ.MT.6300149

1 reference

Europe PubMed Central

PubMed publication ID

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30 December 2019

PubMed publication ID

1 reference

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PubMed publication ID

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30 December 2019

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