(Q40054309)

English

DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

scientific article published on 8 November 2007

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10 January 2020

DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B (English)

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10 January 2020

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DNA methylation

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Umesh T Sankpal

3

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10 January 2020

Keith D. Robertson

5

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10 January 2020

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Stela S Palii

1

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10 January 2020

Beth O Van Emburgh

2

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10 January 2020

Kevin D Brown

4

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10 January 2020

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8 November 2007

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10 January 2020

Molecular and Cellular Biology

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10 January 2020

28

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10 January 2020

2

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10 January 2020

752-771

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10 January 2020

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

1 reference

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Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

1 reference

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DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells

1 reference

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Specific role of Chk1 phosphorylations in cell survival and checkpoint activation

1 reference

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DNA methyltransferase 1 knockdown activates a replication stress checkpoint.

1 reference

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22 September 2017

Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival

1 reference

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Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

1 reference

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1 reference

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

1 reference

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The role of double-strand break repair — insights from human genetics

1 reference

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Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

1 reference

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Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection.

1 reference

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22 September 2017

DNA damage checkpoints in mammals

1 reference

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22 September 2017

Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells

1 reference

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Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe

1 reference

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22 September 2017

DNA methylation and human disease

1 reference

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22 September 2017

Pharmacology of 5-Aza-2'-deoxycytidine (decitabine).

1 reference

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22 September 2017

Decitabine dosing schedules.

1 reference

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22 September 2017

Recruitment of DNA methyltransferase I to DNA repair sites

1 reference

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22 September 2017

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation

1 reference

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22 September 2017

De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint.

1 reference

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22 September 2017

Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters

1 reference

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22 September 2017

5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms

1 reference

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22 September 2017

Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms

1 reference

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22 September 2017

Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells

1 reference

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22 September 2017

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.

1 reference

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22 September 2017

Preferential response of cancer cells to zebularine.

1 reference

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22 September 2017

Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro.

1 reference

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22 September 2017

Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex

1 reference

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22 September 2017

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting

1 reference

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22 September 2017

Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells

1 reference

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22 September 2017

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery

1 reference

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22 September 2017

DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system

1 reference

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22 September 2017

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

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22 September 2017

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

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22 September 2017

Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

1 reference

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22 September 2017

5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.

1 reference

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22 September 2017

Gene silencing in cancer in association with promoter hypermethylation

1 reference

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22 September 2017

The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease

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22 September 2017

Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia

1 reference

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22 September 2017

Chk1 and Chk2 kinases in checkpoint control and cancer

1 reference

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22 September 2017

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

1 reference

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22 September 2017

Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345

1 reference

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22 September 2017

Endogenous assays of DNA methyltransferases: Evidence for differential activities of DNMT1, DNMT2, and DNMT3 in mammalian cells in vivo

1 reference

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22 September 2017

ATM and related protein kinases: safeguarding genome integrity

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22 September 2017

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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22 September 2017

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

1 reference

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22 September 2017

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

1 reference

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22 September 2017

Worms gang up on bacteria

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22 September 2017

Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

1 reference

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22 September 2017

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

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22 September 2017

Histone H2A variants H2AX and H2AZ

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22 September 2017

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

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22 September 2017

DNA methylation patterns and epigenetic memory

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22 September 2017

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements

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22 September 2017

DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination

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22 September 2017

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

1 reference

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22 September 2017

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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22 September 2017

Chromosomal stability and the DNA double-stranded break connection

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22 September 2017

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

1 reference

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22 September 2017

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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22 September 2017

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

1 reference

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22 September 2017

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

1 reference

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22 September 2017

ATM-dependent phosphorylation of nibrin in response to radiation exposure

1 reference

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22 September 2017

Nucleotide excision repair and human syndromes

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22 September 2017

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

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22 September 2017

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

1 reference

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22 September 2017

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

A simple technique for quantitation of low levels of DNA damage in individual cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

22 September 2017

Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

25 September 2017

Recombinant ATM protein complements the cellular A-T phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

25 September 2017

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

15 June 2018

Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

15 June 2018

Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

15 June 2018

Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

15 June 2018

Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Trapped in action: direct visualization of DNA methyltransferase activity in living cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Characterization of DNA demethylation effects induced by 5-Aza-2'-deoxycytidine in patients with myelodysplastic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Selective killing of adriamycin-resistant (G2 checkpoint-deficient and MRP1-expressing) cancer cells by docetaxel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Up-regulation of DNA methyltransferases DNMT1, 3A, and 3B in myelodysplastic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Cytotoxic activity and mechanism of action of 5-Aza-2'-deoxycytidine in human CML cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Cell cycle effects and cellular pharmacology of 5-AZA-2?-deoxycytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2223421

20 August 2018

Increased level of bleomycin-induced chromosome breakage in ataxia telangiectasia skin fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17991895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17991895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17991895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNMT1 knockout delivers a strong blow to genome stability and cell viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/17991895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/17991895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17991895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fundamental role of epigenetic events in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17991895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01799-07

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991895%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991895%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991895%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

ResearchGate publication ID

0 references

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