(Q40001553)

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4 January 2020

title

Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle (English)

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4 January 2020

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GOA release 2020-03-11

Toll Dmel_CG5490

1 reference

GOA release 2020-03-11

author

Monique Gangloff

1

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4 January 2020

Ayaluru Murali

2

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4 January 2020

Alexander N Weber

5

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4 January 2020

Carol V. Robinson

7

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4 January 2020

author name string

Jin Xiong

3

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4 January 2020

Christopher J Arnot

4

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4 January 2020

Alan M Sandercock

6

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4 January 2020

Robert Sarisky

8

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4 January 2020

Andreas Holzenburg

9

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4 January 2020

Cheng Kao

10

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4 January 2020

Nicholas J Gay

11

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4 January 2020

language of work or name

English

0 references

publication date

17 March 2008

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Journal of Biological Chemistry

4 January 2020

published in

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4 January 2020

volume

283

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4 January 2020

issue

21

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4 January 2020

page(s)

14629-14635

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Toll-like receptor signalling

4 January 2020

cites work

1 reference

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Structure and function of Toll receptors and their ligands

21 January 2018

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The immune response of Drosophila

21 January 2018

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Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

21 January 2018

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The molecular structure of the Toll-like receptor 3 ligand-binding domain.

21 January 2018

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Multiple isoforms of the Drosophila Spätzle protein are encoded by alternatively spliced maternal mRNAs in the precellular blastoderm embryo.

21 January 2018

1 reference

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Getting knotted: a model for the structure and activation of Spätzle.

21 January 2018

1 reference

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Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

21 January 2018

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Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway.

21 January 2018

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Toll-like receptors as molecular switches

21 January 2018

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Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand

21 January 2018

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Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency

21 January 2018

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Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation

21 January 2018

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21 January 2018

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UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

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21 January 2018

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Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

21 January 2018

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Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

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21 January 2018

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Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer

21 January 2018

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21 January 2018

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21 January 2018

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Collisional cooling of large ions in electrospray mass spectrometry

21 January 2018

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Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain

21 January 2018

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Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo

21 January 2018

1 reference

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Multimerization and interaction of Toll and Spätzle in Drosophila

21 January 2018

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The role of mass spectrometry in structure elucidation of dynamic protein complexes

21 January 2018

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Evidence for macromolecular protein rings in the absence of bulk water.

21 January 2018

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Origin of asymmetric charge partitioning in the dissociation of gas-phase protein homodimers

21 January 2018

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

21 January 2018

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Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

21 January 2018

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 January 2018

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Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

21 January 2018

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Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

21 January 2018

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Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

21 January 2018

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M800112200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18347020%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference