(Q39893812)

15 September 2017

title

Repression of Gadd45alpha by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation (English)

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15 September 2017

M Perugini

1

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15 September 2017

C H Kok

2

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15 September 2017

A L Brown

3

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15 September 2017

C R Wilkinson

4

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15 September 2017

D G Salerno

5

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15 September 2017

S M Young

6

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15 September 2017

S M Diakiw

7

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15 September 2017

I D Lewis

8

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15 September 2017

T J Gonda

9

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15 September 2017

R J D'Andrea

10

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15 September 2017

publication date

8 January 2009

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15 September 2017

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15 September 2017

volume

23

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15 September 2017

issue

4

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15 September 2017

page(s)

729-738

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FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia

15 September 2017

cites work

1 reference

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Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

21 January 2018

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Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.

21 January 2018

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FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

21 January 2018

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The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

21 January 2018

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Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

21 January 2018

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Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

21 January 2018

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

21 January 2018

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RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation.

21 January 2018

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Continuous ERK activation downregulates antiproliferative genes throughout G1 phase to allow cell-cycle progression.

21 January 2018

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GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.349

GADD45 induction of a G2/M cell cycle checkpoint

21 January 2018

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Gadd45 modulation of intrinsic and extrinsic stress responses in myeloid cells

21 January 2018

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Gadd45 in stress signaling

21 January 2018

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Egad, more forms of gene regulation: the gadd45a story

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.349

Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis

21 January 2018

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Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence.

21 January 2018

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Genetic regulators of myelopoiesis and leukemic signaling identified by gene profiling and linear modeling.

21 January 2018

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Constitutive mutants of the GM-CSF receptor reveal multiple pathways leading to myeloid cell survival, proliferation, and granulocyte-macrophage differentiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2008.349

An improved method for generating retroviral producer clones for vectors lacking a selectable marker gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Myeloproliferative disorder and leukaemia in mice induced by different classes of constitutive mutants of the human IL-3/IL-5/GM-CSF receptor common beta subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Signal transduction of oncogenic Flt3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Prognostically useful gene-expression profiles in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

AML1B transcriptional repressor function is impaired by the Flt3-internal tandem duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Cell cycle: sustained ERK signalling represses the inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Role of Gadd45 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Cytokine response gene 6 induces p21 and regulates both cell growth and arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Hematopoietic cells from gadd45a-deficient and gadd45b-deficient mice exhibit impaired stress responses to acute stimulation with cytokines, myeloablation and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

C/EBPalpha regulation of the growth-arrest-associated gene gadd45.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Reciprocal regulation of gadd45 by C/EBP alpha and c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

7 January 2021

Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

7 January 2021

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

7 January 2021

Genomic instability in Gadd45a-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

7 January 2021

Gadd45a acts as a modifier locus for lymphoblastic lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

7 January 2021

Life and death in cancer. GADD45 alpha and gamma are critical regulators of NF-kappaB mediated escape from programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2008.349

7 January 2021

Identifiers

DOI

10.1038/LEU.2008.349

1 reference

Dimensions Publication ID

15 September 2017

1030548993

0 references

1 reference