(Q39696868)

14 September 2017

Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair (English)

1 reference

14 September 2017

Haleli Sharir

1

1 reference

14 September 2017

Anna Zinger

2

1 reference

14 September 2017

Andrey Nevo

3

1 reference

14 September 2017

Israel Sekler

4

1 reference

14 September 2017

Michal Hershfinkel

5

1 reference

14 September 2017

language of work or name

English

0 references

publication date

3 June 2010

1 reference

Journal of Biological Chemistry

14 September 2017

1 reference

14 September 2017

285

1 reference

14 September 2017

34

1 reference

14 September 2017

26097-26106

1 reference

describes a project that uses

14 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2924011/fullTextXML

inferred from PubMed Central ID database lookup

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Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus

14 September 2017

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Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis.

14 September 2017

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Requirement for metalloproteinase-dependent ERK and AKT activation in UVB-induced G1-S cell cycle progression of human keratinocytes

14 September 2017

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Regulation and function of Zip4, the acrodermatitis enteropathica gene

14 September 2017

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Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations

14 September 2017

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Intracellular zinc homeostasis and zinc signaling

14 September 2017

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Bullous lesions in acrodermatitis enteropathica delaying diagnosis of zinc deficiency: a report of two cases and review of the literature

14 September 2017

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The genetics of essential metal homeostasis during development

14 September 2017

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Protons extruded by NHE1: digestive or glue?

14 September 2017

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Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum

14 September 2017

1 reference

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Cell volume regulatory ion channels in cell proliferation and cell death

14 September 2017

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LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway

14 September 2017

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Mitogenic signaling pathways induced by G protein-coupled receptors

14 September 2017

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The zinc sensing receptor, a link between zinc and cell signaling

14 September 2017

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Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium

14 September 2017

1 reference

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Injury and nucleotides induce phosphorylation of epidermal growth factor receptor: MMP and HB-EGF dependent pathway

14 September 2017

1 reference

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Zinc in wound healing: theoretical, experimental, and clinical aspects.

14 September 2017

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Zinc and skin health: overview of physiology and pharmacology

14 September 2017

1 reference

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ATP-dependent paracrine intercellular communication in cultured bovine corneal endothelial cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

The Na+/H+ exchanger isoform 1.

14 September 2017

1 reference

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Na(+)/H(+) exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Detecting and minimizing zinc contamination in physiological solutions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Diversity of the mammalian sodium/proton exchanger SLC9 gene family

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization

14 September 2017

1 reference

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Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.

14 September 2017

1 reference

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The changing face of the Na+/H+ exchanger, NHE1: structure, regulation, and cellular actions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

A zinc-sensing receptor triggers the release of intracellular Ca2+ and regulates ion transport

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Mechanisms of epithelial fusion and repair.

14 September 2017

1 reference

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Matrix metalloproteinases in wound repair (review).

14 September 2017

1 reference

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14 September 2017

1 reference

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Hypoxia increases human keratinocyte motility on connective tissue.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Localization of neuronal and glial glutamate transporters

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Effects of extracellular calcium on the growth-differentiation switch in immortalized keratinocyte HaCaT cells compared with normal human keratinocytes.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

G alpha(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Wound-induced ATP release and EGF receptor activation in epithelial cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Mitogen-activated protein kinase-dependent activation of the Na+/H+ exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Protein kinase C (PKC)-delta/-epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

The extracellular zinc-sensing receptor mediates intercellular communication by inducing ATP release.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through the PI3-kinase/Akt/mTOR/p70S6K1 signaling pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Cellular injury induces activation of MAPK via P2Y receptors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrins

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Extracellular calcium stimulates DNA synthesis in synergism with zinc, insulin and insulin-like growth factor I in fibroblasts

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Zinc deprivation of murine 3T3 cells by use of diethylenetrinitrilopentaacetate impairs DNA synthesis upon stimulation with insulin-like growth factor-1 (IGF-1).

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Bombesin and zinc enhance the synergistic mitogenic effects of insulin and phosphocholine by a MAP kinase-dependent mechanism in Swiss 3T3 cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Addition of zinc and manganese to a biological dressing

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

A distinct role in breast cancer for two LIV-1 family zinc transporters.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Extracellular zinc and zinc-citrate, acting through a putative zinc-sensing receptor, regulate growth and survival of prostate cancer cells

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Airway epithelial cell migration and wound repair by ATP-mediated activation of dual oxidase 1.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Extracellular pH Controls NHE1 expression in epidermis and keratinocytes: implications for barrier repair

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Modification of PI3K- and MAPK-dependent chemotaxis in aortic vascular smooth muscle cells by protein kinase CbetaII.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

YM-254890 analogues, novel cyclic depsipeptides with Galpha(q/11) inhibitory activity from Chromobacterium sp. QS3666.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Improvement and biological applications of fluorescent probes for zinc, ZnAFs

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Molecular and functional characterization of sodium--hydrogen exchanger in skin as well as cultured keratinocytes and melanocytes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2924011

Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies

20 August 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.107490

MAPKAPK-2 Signaling Is Critical for Cutaneous Wound Healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.107490

Transcriptional Signature of Epidermal Keratinocytes Subjected toin VitroScratch Wounding Reveals Selective Roles for ERK1/2, p38, and Phosphatidylinositol 3-Kinase Signaling Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.107490

Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.107490

Zinc in the healing wound

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20522546

12 December 2020

How do injured cells communicate with the surviving cell monolayer?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20522546

12 December 2020

Non-invasive in vivo methods for investigation of the skin barrier physical properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/20522546

12 December 2020

Effects of zinc deficient diet on development of atopic dermatitis-like eruptions in DS-Nh mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20522546

12 December 2020

Novel Zinc Fluorescent Probes Excitable with Visible Light for Biological Applications We thank Prof. E. Kimura and Prof. T. Koike for advice on the chemistry of macrocyclic polyamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20522546

12 December 2020

Fluorescence-based zinc ion sensor for zinc ion release from pancreatic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20522546

12 December 2020

Roles of mitogen-activated protein kinases and protein kinase C in alpha(1A)-adrenoceptor-mediated stimulation of the sarcolemmal Na(+)-H(+) exchanger

1 reference

https://pubmed.ncbi.nlm.nih.gov/20522546

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.107490

1 reference

14 September 2017

1 reference

14 September 2017

PubMed publication ID

20522546

1 reference