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p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.
scientific article published on February 1999
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
title
p73 function is inhibited by tumor-derived p53 mutants in mammalian cells
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
author
Charles DiComo
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
Christian Gaiddon
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
author name string
C Prives
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
language of work or name
English
0 references
publication date
1 February 1999
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
published in
Molecular and Cellular Biology
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
volume
19
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
issue
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
page(s)
1438-1449
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
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PubMed Central
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Cloning and functional analysis of human p51, which structurally and functionally resembles p53
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Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain
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An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control
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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
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Identification of redox/repair protein Ref-1 as a potent activator of p53
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p53, the cellular gatekeeper for growth and division
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14 September 2017
Identification of a novel p53 functional domain that is necessary for efficient growth suppression
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14 September 2017
Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein
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14 September 2017
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
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14 September 2017
p53: puzzle and paradigm
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14 September 2017
Apoptosis: molecular regulation of cell death
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14 September 2017
The p53 protein is an unusually shaped tetramer that binds directly to DNA.
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14 September 2017
Several mutant p53 proteins detected in cancer-prone families with Li-Fraumeni syndrome exhibit transdominant effects on the biochemical properties of the wild-type p53.
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14 September 2017
Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression
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14 September 2017
A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein
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14 September 2017
Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
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14 September 2017
Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP
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14 September 2017
Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells
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14 September 2017
High-resolution structure of the oligomerization domain of p53 by multidimensional NMR
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14 September 2017
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
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14 September 2017
Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
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14 September 2017
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
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14 September 2017
Role of cysteine residues in regulation of p53 function
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Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.
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14 September 2017
The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity
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14 September 2017
Solution structure of the tetrameric minimum transforming domain of p53
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14 September 2017
A simple p53 functional assay for screening cell lines, blood, and tumors
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14 September 2017
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation
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14 September 2017
Induction of the growth inhibitor IGF-binding protein 3 by p53
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14 September 2017
Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
Activators and targets
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PubMed Central
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14 September 2017
Identification of p53 as a sequence-specific DNA-binding protein
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
Analysis of p53 mutants for transcriptional activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
Oncogenic forms of p53 inhibit p53-regulated gene expression
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
p53 function and dysfunction
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
Transcriptional activation of the human epidermal growth factor receptor promoter by human p53.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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14 September 2017
Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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25 September 2017
p53 in growth control and neoplasia
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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25 September 2017
p73 is a simian [correction of human] p53-related protein that can induce apoptosis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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25 September 2017
Inhibition of mouse thymidylate synthase promoter activity by the wild-type p53 tumor suppressor protein
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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25 September 2017
Genomic effects of the putative oncogene G alpha s. Chronic transcriptional activation of the c-fos proto-oncogene in endocrine cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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25 September 2017
Response of heat shock element within the human HSP70 promoter to mutated p53 genes.
1 reference
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PubMed Central
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25 September 2017
A second p53-related protein, p73L, with high homology to p73.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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17 June 2018
Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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17 June 2018
p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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17 June 2018
Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.
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PubMed Central
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17 June 2018
Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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17 June 2018
Presence of a potent transcription activating sequence in the p53 protein
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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17 June 2018
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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17 June 2018
Tumor suppressor p53: analysis of wild-type and mutant p53 complexes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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17 June 2018
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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17 June 2018
Monitoring adenoviral p53 transduction efficiency by yeast functional assay
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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21 August 2018
A novel protein with strong homology to the tumor suppressor p53.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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21 August 2018
p53 domains: identification and characterization of two autonomous DNA-binding regions.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116072
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21 August 2018
Wild-type p53 activates transcription in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9891077
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9891077
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mutant p53 proteins behave in a dominant, negative fashion in vivo
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9891077
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Screening patients for heterozygous p53 mutations using a functional assay in yeast
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9891077
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9891077
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9891077
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9891077
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9891077
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.19.2.1438
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
PMC publication ID
116072
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
PubMed publication ID
9891077
1 reference
stated in
Europe PubMed Central
PMC publication ID
116072
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891077%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
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