Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q39454531)
Watch
English
The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
scientific article published in August 2000
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
title
The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
author
Elisabeth Génot
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
Cécile ARRIEUMERLOU
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
author name string
G Ku
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
B M Burgering
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
A Weiss
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
I M Kramer
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
language of work or name
English
0 references
publication date
1 August 2000
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
published in
Molecular and Cellular Biology
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
volume
20
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
issue
15
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
page(s)
5469-5478
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
cites work
Signalling through the insulin receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Rho GTPases and signaling networks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Mechanism of activation of protein kinase B by insulin and IGF-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Rac GTPase interacts specifically with phosphatidylinositol 3-kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Phosphatidylinositol-3-OH kinase as a direct target of Ras
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Rho Family GTPases Bind to Phosphoinositide Kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
12 September 2017
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
14 September 2017
Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
14 September 2017
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
14 September 2017
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
25 September 2017
Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
25 September 2017
Involvement of phosphoinositide 3-kinase and Rac in membrane ruffling induced by IL-2 in T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
25 September 2017
Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
25 September 2017
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
25 September 2017
T cell antigen receptor signal transduction pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
25 September 2017
Multiple p21ras effector pathways regulate nuclear factor of activated T cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
25 September 2017
Akt activation by growth factors is a multiple-step process: the role of the PH domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
17 June 2018
Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
17 June 2018
Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
17 June 2018
Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
17 June 2018
Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
17 June 2018
A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
21 August 2018
Structure and function of phosphoinositide 3-kinases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
21 August 2018
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
21 August 2018
Regulation of inositol lipid kinases by Rho and Rac.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
21 August 2018
A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
4 November 2018
Stimulation of p21 ras upon T-cell activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85998
retrieved
2 December 2018
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10891487
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor zeta subunits and the CD3 gamma, delta and epsilon chains
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10891487
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10891487
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10891487
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.20.15.5469-5478.2000
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
PMC publication ID
85998
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
PubMed publication ID
10891487
1 reference
stated in
Europe PubMed Central
PMC publication ID
85998
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10891487%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit