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The role of annexin A2 in tumorigenesis and cancer progression
scientific article published on 05 March 2011
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Europe PubMed Central
PMC publication ID
3170418
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
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12 February 2020
review article
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Europe PubMed Central
title
The role of annexin A2 in tumorigenesis and cancer progression
(English)
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Europe PubMed Central
PMC publication ID
3170418
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 February 2020
author
Noor A Lokman
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1
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Europe PubMed Central
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3170418
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
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12 February 2020
Miranda P Ween
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2
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Europe PubMed Central
PMC publication ID
3170418
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 February 2020
Carmela Ricciardelli
series ordinal
4
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Europe PubMed Central
PMC publication ID
3170418
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 February 2020
author name string
Martin K Oehler
series ordinal
3
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Europe PubMed Central
PMC publication ID
3170418
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
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12 February 2020
language of work or name
English
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publication date
5 March 2011
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Europe PubMed Central
PMC publication ID
3170418
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 February 2020
published in
Cancer Microenvironment
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Europe PubMed Central
PMC publication ID
3170418
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 February 2020
volume
4
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Europe PubMed Central
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3170418
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12 February 2020
issue
2
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Europe PubMed Central
PMC publication ID
3170418
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 February 2020
page(s)
199-208
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Europe PubMed Central
PMC publication ID
3170418
reference URL
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retrieved
12 February 2020
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Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects
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Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer
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Silencing of the annexin II gene down-regulates the levels of S100A10, c-Myc, and plasmin and inhibits breast cancer cell proliferation and invasion.
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Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via tPA dependent plasmin generation
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Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147.
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Comprehensive analysis of conditioned media from ovarian cancer cell lines identifies novel candidate markers of epithelial ovarian cancer
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Overexpression of Annexin II affects the proliferation, apoptosis, invasion and production of proangiogenic factors in multiple myeloma
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Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy
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14 September 2017
Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells.
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14 September 2017
Increased expression of Annexin A2 in oral squamous cell carcinoma
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14 September 2017
Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces
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14 September 2017
Annexin II overexpression predicts rapid recurrence after surgery in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy
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14 September 2017
Annexin A2 regulates the levels of plasmin, S100A10 and Fascin in L5178Y cells
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14 September 2017
Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
14 September 2017
Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
14 September 2017
Involvement of Annexin A2 in p53 induced apoptosis in lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
14 September 2017
Angiogenesis-associated protein annexin II in breast cancer: selective expression in invasive breast cancer and contribution to tumor invasion and progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
14 September 2017
Knockdown of annexin 2 decreases migration of human glioma cells in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
14 September 2017
Annexin II cell surface and mRNA expression in human acute myeloid leukaemia cell lines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
14 September 2017
Annexin 2 expression is reduced in human osteosarcoma metastases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
14 September 2017
Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
14 September 2017
New insights into the tPA-annexin A2 interaction. Is annexin A2 CYS8 the sole requirement for this association?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
14 September 2017
Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
27 September 2017
Annexin II overexpression correlates with stromal tenascin-C overexpression: a prognostic marker in colorectal carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
27 September 2017
Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
27 September 2017
Annexin II tetramer: structure and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
27 September 2017
Detection of secreted and intracellular annexin II by a radioimmunoassay
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
27 September 2017
Annexin A2 localizes to the basal epithelial layer and is down-regulated in dysplasia and head and neck squamous cell carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
23 June 2018
Early detection of ovarian cancer using group biomarkers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
23 June 2018
Reduced annexin II protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
23 June 2018
Secretion of Annexin II via activation of insulin receptor and insulin-like growth factor receptor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
23 June 2018
Collagen-binding proteins of mammary epithelial cells are related to Ca2(+)- and phospholipid-binding annexins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
23 June 2018
The tight association of the tyrosine kinase substrate annexin II with the submembranous cytoskeleton depends on intact p11- and Ca(2+)-binding sites
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
23 June 2018
Developmental regulation of annexin II (Lipocortin 2) in human brain and expression in high grade glioma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
23 June 2018
Characterization of phosphoproteins in gastric cancer secretome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Polymeric nanoparticles for sustained down-regulation of annexin A2 inhibit prostate tumor growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Angiostatin receptor annexin II in vascular tumors including angiosarcoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Evaluation of S100A10, annexin II and B-FABP expression as markers for renal cell carcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Chromosomal region 15q21.1 is a frequent target of allelic imbalance in advanced breast carcinomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Angiostatin binds to tyrosine kinase substrate annexin II through the lysine-binding domain in endothelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Arsenic trioxide, retinoic acid and Ara-c regulated the expression of annexin II on the surface of APL cells, a novel co-receptor for plasminogen/tissue plasminogen activator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Neuritogenesis and the nerve growth factor-induced differentiation of PC-12 cells requires annexin II-mediated plasmin generation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Loss of annexin II heavy and light chains in prostate cancer and its precursors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
The p11 subunit of the annexin II tetramer plays a key role in the stimulation of t-PA-dependent plasminogen activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Expression of annexin II in glioma cell lines and in brain tumor biopsies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Annexin II marks astrocytic brain tumors of high histologic grade.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3170418
retrieved
31 August 2018
Expression of annexins on the surfaces of non-metastatic and metastatic human and rodent tumor cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Expression of annexin II in conventional renal cell carcinoma is correlated with Fuhrman grade and clinical outcome
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Tyrosine phosphorylation of annexin II tetramer is stimulated by membrane binding
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Antibody-directed targeting of angiostatin's receptor annexin II inhibits Lewis Lung Carcinoma tumor growth via blocking of plasminogen activation: possible biochemical mechanism of angiostatin's action
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Enhanced expression of annexin II in human pancreatic carcinoma cells and primary pancreatic cancers
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The plasminogen activator system in pancreas cancer: role of t-PA in the invasive potential in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Increased expression of annexin A3 is a mechanism of platinum resistance in ovarian cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Extracellular annexin II is associated with divalent cation-dependent tumor cell-endothelial cell adhesion of metastatic RAW117 large-cell lymphoma cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21909879
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1007/S12307-011-0064-9
1 reference
stated in
Europe PubMed Central
PMC publication ID
3170418
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 February 2020
Dimensions Publication ID
1045651580
0 references
PMC publication ID
3170418
1 reference
stated in
Europe PubMed Central
PMC publication ID
3170418
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 February 2020
PubMed publication ID
21909879
1 reference
stated in
Europe PubMed Central
PMC publication ID
3170418
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909879%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 February 2020
ResearchGate publication ID
51630557
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