(Q38301871)

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29 October 2019

title

Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells (English)

1 reference

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29 October 2019

2

1 reference

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29 October 2019

Stefan Rose-John

3

1 reference

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29 October 2019

author name string

F D de Hon

1

1 reference

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29 October 2019

S B Ebeling

4

1 reference

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29 October 2019

H K Bos

5

1 reference

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29 October 2019

L A Aarden

6

1 reference

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29 October 2019

J P Brakenhoff

7

1 reference

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29 October 2019

language of work or name

English

0 references

publication date

1 December 1994

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7964514%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

29 October 2019

published in

1 reference

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29 October 2019

volume

180

1 reference

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29 October 2019

issue

6

1 reference

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29 October 2019

page(s)

2395-2400

1 reference

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IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

29 October 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Cytokine signal transduction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Interleukin-6 and its receptor: a paradigm for cytokines

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Identification of a receptor binding site in the carboxyl terminus of human interleukin-6

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

The alphas, betas, and kinases of cytokine receptor complexes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Interleukin-6 in biology and medicine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Human soluble IL-6 receptor: its detection and enhanced release by HIV infection

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Protective effect of anti-interleukin (IL)-6 antibody against endotoxin, associated with paradoxically increased IL-6 levels

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191796

Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy

23 June 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/7964514

12 December 2020

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/7964514

12 December 2020

Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/7964514

12 December 2020

Brief report: alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/7964514

12 December 2020

Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/7964514

12 December 2020

Identifiers

DOI

10.1084/JEM.180.6.2395

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7964514%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7964514%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

PubMed publication ID

7964514

1 reference