(Q38037753)

27 August 2017

title

The therapeutic target Hsp90 and cancer hallmarks (English)

1 reference

27 August 2017

3

Len Neckers

1 reference

27 August 2017

Yoshihiko Miyata

1

1 reference

27 August 2017

Hitoshi Nakamoto

series ordinal

2

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27 August 2017

publication date

1 January 2013

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27 August 2017

number of pages

19

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Current Pharmaceutical Design

inferred from page(s)

published in

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27 August 2017

volume

19

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27 August 2017

issue

3

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27 August 2017

page(s)

347-365

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Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II.

27 August 2017

cites work

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Expression of Hsp90 chaperone [corrected] proteins in human tumor tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Targeting the oncogene and kinome chaperone CDC37.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The hsp90 molecular chaperone modulates multiple telomerase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Functional importance of heat shock protein 90 associated with insulin receptor on insulin-stimulated mitogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

HSP90 and the chaperoning of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Molecular chaperones and protein kinase quality control.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/22920906

1 reference

12 December 2020

Structure and mechanism of the Hsp90 molecular chaperone machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Telomeres, chromosome instability and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Characterization of a plastid-specific HSP90 homologue: identification of a cDNA sequence, phylogenetic descendence and analysis of its mRNA and protein expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Heat shock proteins in cancer: chaperones of tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The death-associated protein kinases: structure, function, and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Calreticulin and Hsp90 stabilize the human insulin receptor and promote its mobility in the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Androgen receptor structural and functional elements: role and regulation in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

In vitro assembly of plant RNA-induced silencing complexes facilitated by molecular chaperone HSP90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hallmarks of Cancer: The Next Generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Fibroblast growth factor receptor 3 (FGFR3) is a strong heat shock protein 90 (Hsp90) client: implications for therapeutic manipulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Supervision of multiple signaling protein kinases by the CK2-Cdc37 couple, a possible novel cancer therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Cdc37 is a molecular chaperone with specific functions in signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The cellular geography of aurora kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Stimulation of the weak ATPase activity of human hsp90 by a client protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Epithelial cell polarity, stem cells and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A novel MAP kinase regulates flagellar length in Chlamydomonas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Cross-talk between peptide growth factor and estrogen receptor signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Association of the Transforming Proteins of Rous, Fujinami, and Y73 Avian Sarcoma Viruses with the Same Two Cellular Proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The 'active life' of Hsp90 complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

One-thousand-and-one substrates of protein kinase CK2?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Chaperoning steroid hormone action

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Interaction between Cdc37 and Cdk4 in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A mouse tumor-specific transplantation antigen is a heat shock-related protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Regulation of Cdc2 activity by phosphorylation at T14/Y15

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Chaperone ligand-discrimination by the TPR-domain protein Tah1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Estrogen receptors: how do they signal and what are their targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The Hsp82 molecular chaperone promotes a switch between unextendable and extendable telomere states

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Chaperoning oncogenes: Hsp90 as a target of geldanamycin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Physical interaction of mammalian CDC37 with CDK4

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 Recognizes a Common Surface on Client Kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Antiapoptotic function of Bcl-2 in mast cells is dependent on its association with heat shock protein 90beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Differential in vivo regulation of steroid hormone receptor activation by Cdc37p

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Untangling the ErbB signalling network

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Telomere biology in Metazoa

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Polo-like kinases: positive regulators of cell division from start to finish.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Inhibitors of angiogenesis and cancer-related receptor tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Discovery and development of aurora kinase inhibitors as anticancer agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Oncogenic mutations reduce the stability of SRC kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Conformational dynamics of the molecular chaperone Hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The mTOR pathway and its role in human genetic diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Targeting CK2 for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 chaperones wild-type p53 tumor suppressor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Cdc37 goes beyond Hsp90 and kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

p53 Research: the past thirty years and the next thirty years.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Structure of Minimal Tetratricopeptide Repeat Domain Protein Tah1 Reveals Mechanism of Its Interaction with Pih1 and Hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

An acetylation site in the middle domain of Hsp90 regulates chaperone function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

RAF protein-serine/threonine kinases: Structure and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The cancer stem cell: premises, promises and challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Maturation of steroid receptors: an example of functional cooperation among molecular chaperones and their associated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mechanism of Dimer Formation of the 90‐kDa Heat‐Shock Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Cdc37: a protein kinase chaperone?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Addiction to protein kinase CK2: a common denominator of diverse cancer cells?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

MAP kinase signalling pathways in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Challenges to defining a role for progesterone in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90: chaperoning signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Modulating molecular chaperone Hsp90 functions through reversible acetylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 and co-chaperones twist the functions of diverse client proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Telomerase and cancer therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Critical regulation of TGFbeta signaling by Hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Dual role of heat shock proteins as regulators of apoptosis and innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Phosphorylation and hsp90 binding mediate heat shock stabilization of p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Androgen receptor and growth factor signaling cross-talk in prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Signal transduction: Gyrating protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

HtpG, the prokaryotic homologue of Hsp90, stabilizes a phycobilisome protein in the cyanobacterium Synechococcus elongatus PCC 7942

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The role of HSP90 in evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Protein folding sculpting evolutionary change

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Raf kinases: function, regulation and role in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Protein kinase CK2: a new view of an old molecular complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Interaction of the Rous sarcoma virus protein pp60src with the cellular proteins pp50 and pp90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Androgen receptor and its splice variants in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Targeting CDC37: an alternative, kinase-directed strategy for disruption of oncogenic chaperoning

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The Hsp90 chaperone machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The complexity of Raf-1 regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A direct role for Hsp90 in pre-RISC formation in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Blockade of the HER family of receptors in the treatment of HER2-positive metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Murine protein kinase CK2: gene and oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The microRNA pathway and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated Cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The Hallmarks of Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

VEGF as a key mediator of angiogenesis in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The raison d'être of constitutively active protein kinases: the lesson of CK2

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

CDC37 is required for p60v-src activity in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The many faces of Src: multiple functions of a prototypical tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Regulation of the Src family kinase Lck by Hsp90 and ubiquitination

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Interaction between casein kinase II and the 90-kDa stress protein, HSP90

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Fibroblast growth factor signalling: from development to cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Structure of an Hsp90-Cdc37-Cdk4 complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Functional requirement of p23 and Hsp90 in telomerase complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Inhibition of Hsp90: a new strategy for inhibiting protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Modulation of Akt kinase activity by binding to Hsp90

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Association of the heat shock protein hsp90 with steroid hormone receptors and tyrosine kinase oncogene products

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

BCR-ABL in chronic myelogenous leukemia--how does it work?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The Aurora kinase family in cell division and cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Cyclin D as a therapeutic target in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 levels affect telomere length in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Bax: Addressed to kill

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Steroid receptor interactions with heat shock protein and immunophilin chaperones

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Heat shock protein 90 as a molecular target for cancer therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Cyclin dependent kinases and cell cycle control (nobel lecture).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/22920906

1 reference

12 December 2020

Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

MicroRNA regulation by RNA-binding proteins and its implications for cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Estrogen receptor and breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Shared and separate functions of polo-like kinases and aurora kinases in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Polo-like kinases: conservation and divergence in their functions and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Chaperoning of glucocorticoid receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Molecular mechanisms of tumor suppression by LKB1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Order or chaos? An evaluation of the regulation of protein kinase CK2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Mammalian cyclin-dependent kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p

1 reference

https://pubmed.ncbi.nlm.nih.gov/22920906

12 December 2020

10.2174/138161213804143725

Identifiers

DOI

1 reference

27 August 2017

0 references

1 reference