(Q37942677)

English

The signal peptide

scientific article published on May 1990

In more languages

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

1 reference

Europe PubMed Central

The signal peptide (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

Gunnar von Heijne

1

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

publication date

1 May 1990

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

number of pages

7

1 reference

based on heuristic

inferred from page(s)

Journal of Membrane Biology

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

115

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

195-201

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

Single-amino-acid substitutions within the signal sequence of yeast prepro-alpha-factor affect membrane translocation

1 reference

https://api.crossref.org/works/10.1007%2FBF01868635

21 January 2018

Secretion-defective mutations in the signal sequence for Saccharomyces cerevisiae invertase

1 reference

https://api.crossref.org/works/10.1007%2FBF01868635

21 January 2018

Transcending the impenetrable: how proteins come to terms with membranes

1 reference

https://api.crossref.org/works/10.1007%2FBF01868635

21 January 2018

The role of the positively charged N-terminus of the signal sequence of E. coli outer membrane protein PhoE in export

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Re-routing of a secretory protein by fusion with human growth hormone sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational alterations in the proximal portion of the yeast invertase signal peptide do not block secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topogenic signals in integral membrane proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homologous plant and bacterial proteins chaperone oligomeric protein assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trans-membrane Translocation of Proteins. The Direct Transfer Model

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An alternate pathway for the processing of the prolipoprotein signal peptide in Escherichia coli.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Penetration of the signal sequence of Escherichia coli PhoE protein into phospholipid model membranes leads to lipid-specific changes in signal peptide structure and alterations of lipid organization

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NH2-terminal substitutions of basic amino acids induce translocation across the microsomal membrane and glycosylation of rabbit cytochrome P450IIC2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The distribution of positively charged residues in bacterial inner membrane proteins correlates with the trans-membrane topology

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Many random sequences functionally replace the secretion signal sequence of yeast invertase

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic analysis of lamB mutants suggests the signal sequence plays multiple roles in protein export.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of mutational alterations in the hydrophilic segment of the maltose-binding protein signal peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive charges at the NH2 terminus convert the membrane-anchor signal peptide of cytochrome P-450 to a secretory signal peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A signal sequence receptor in the endoplasmic reticulum membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new method for predicting signal sequence cleavage sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain structure of mitochondrial and chloroplast targeting peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Introduction of basic amino acid residues after the signal peptide inhibits protein translocation across the cytoplasmic membrane of Escherichia coli. Relation to the orientation of membrane proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the complete removal of basic amino acid residues from the signal peptide on secretion of lipoprotein in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the propeptide sequence of human preproparathyroid hormone for signal sequence function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal peptide amino acid sequences in Escherichia coli contain information related to final protein localization. A multivariate data analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the propeptide from human preproapolipoprotein A-II redirects cotranslational processing by signal peptidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The differential effect on two hybrid proteins of deletion mutations within the hydrophobic region of the Escherichia coli OmpA signal peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic studies on protein export in bacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Export defect adjacent to the processing site of staphylococcal nuclease is suppressed by a prlA mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the loop model of signal-sequence insertion into the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytoplasmic domain of Escherichia coli leader peptidase is a "translocation poison" sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Important role of the proline residue in the signal sequence that directs the secretion of human lysozyme in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intragenic suppressor mutations that restore export of maltose binding protein with a truncated signal peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformations of signal peptides induced by lipids suggest initial steps in protein export

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular chaperones: proteins essential for the biogenesis of some macromolecular structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of topology and mode of assembly of a polytopic membrane protein by positively charged residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A signal sequence mutant defective in export of ribose-binding protein and a corresponding pseudorevertant isolated without imposed selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of amino acids near signal-sequence cleavage sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Assembly of Proteins into Biological Membranes: The Membrane Trigger Hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in the cleavage site of the signal sequence for the secretion of human lysozyme by Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intragenic reversion mutations that improve export of maltose-binding protein in Escherichia coli malE signal sequence mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive charges in the cytoplasmic domain of Escherichia coli leader peptidase prevent an apolar domain from functioning as a signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Outer Membrane Proteins of Gram-Negative Bacteria: Biosynthesis, Assembly, and Functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SecA protein, a peripheral protein of the Escherichia coli plasma membrane, is essential for the functional binding and translocation of proOmpA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacteriophage M13 procoat protein inserts into the plasma membrane as a loop structure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How signal sequences maintain cleavage specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The membrane-spanning segment of invariant chain (I gamma) contains a potentially cleavable signal sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformations and orientations of a signal peptide interacting with phospholipid monolayers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of deleting the propeptide from human preproapolipoprotein A-I on co-translational translocation and signal peptidase processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting the orientation of eukaryotic membrane-spanning proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineering of the hydrophobic segment of the signal sequence for efficient secretion of human lysozyme by Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The signal sequence of an Escherichia coli outer membrane protein can mediate translocation of a not normally secreted protein across the plasma membrane.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Escherichia coli SecB protein associates with exported protein precursors in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal peptidases recognize a structural feature at the cleavage site of secretory proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species-specific variation in signal peptide design. Implications for protein secretion in foreign hosts

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The precursor of beta-lactamase: purification, properties and folding kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Export of protein: a biochemical view

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploring the conformational roles of signal sequences: synthesis and conformational analysis of lambda receptor protein wild-type and mutant signal peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the effects of mutations in the basic region of the OmpA signal peptide by the mature portion of the protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of a signal peptide by protease IV and oligopeptidase A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An inner membrane protein N-terminal signal sequence is able to promote efficient localisation of an outer membrane protein in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eukaryotic signal peptide structure/function relationships. Identification of conformational features which influence the site and efficiency of co-translational proteolytic processing by site-directed mutagenesis of human pre(delta pro)apolipoprote

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations to the signal peptide of an outer membrane protein (OmpA) of Escherichia coli K-12 can promote either the cotranslational or the posttranslational mode of processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leader peptidase catalyzes the release of exported proteins from the outer surface of the Escherichia coli plasma membrane.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Net N-C charge imbalance may be important for signal sequence function in bacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of the amino terminus of the mature sequence of a periplasmic protein can severely affect protein export in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of eukaryotic signal peptidase. Site-saturation mutagenesis at position -1 regulates cleavage between multiple sites in human pre (delta pro) apolipoprotein A-II

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational alterations affecting the export competence of a truncated but fully functional maltose-binding protein signal peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the interfacial behavior and structure of the signal sequence of Escherichia coli outer membrane pore protein PhoE

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein secretion in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of amino-terminal positive charge on signal peptide in staphylokinase export across the cytoplasmic membrane of Escherichia coli.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of signal sequence mutations on the kinetics of alkaline phosphatase export to the periplasm in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial protein import

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of PhoE translocation across Escherichia coli inner-membrane vesicles by synthetic signal peptides suggests an important role of acidic phospholipids in protein translocation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the amino-terminal domain of asialoglycoprotein receptor H1 allows cleavage of the internal signal sequence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of secondary structure in the signal sequence for protein secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of signal peptides from bacterial lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Misplacement of the amino-terminal positive charge in the prepro-alpha-factor signal peptide disrupts membrane translocation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three pure chaperone proteins of Escherichia coli--SecB, trigger factor and GroEL--form soluble complexes with precursor proteins in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of a signal sequence mutation by an amino acid substitution in the mature portion of the maltose-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retardation of folding as a possible means of suppression of a mutation in the leader sequence of an exported protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of protein secretion: the role of the signal sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylglycerol is involved in protein translocation across Escherichia coli inner membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the distribution of charged residues in the N-terminal region of signal sequences: implications for protein export in prokaryotic and eukaryotic cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/2197415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01868635

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 August 2017

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