(Q37804460)

English

The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells

scientific article published on October 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

11 references

13 March 2019

14 March 2019

24 March 2019

20 June 2019

5 August 2019

8 September 2019

19 September 2019

7 October 2019

10 October 2019

27 January 2021

4 February 2021

The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells (English)

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

endoplasmic reticulum

0 references

experimental diabetes mellitus

3 references

13 March 2019

14 March 2019

24 March 2019

type 2 diabetes

6 references

5 August 2019

8 September 2019

19 September 2019

7 October 2019

10 October 2019

4 February 2021

1 reference

5 August 2019

regulation of gene expression

1 reference

8 September 2019

biomedical investigative technique

1 reference

19 September 2019

human digestive system

1 reference

7 October 2019

endocrine system

1 reference

10 October 2019

insulin-secreting cells

1 reference

27 January 2021

author name string

R J Kaufman

1

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

S H Back

2

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

B Song

3

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

J Han

4

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

J Hassler

5

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 October 2010

12 references

Europe PubMed Central

PMC publication ID

23 August 2017

13 March 2019

14 March 2019

24 March 2019

20 June 2019

5 August 2019

8 September 2019

19 September 2019

7 October 2019

10 October 2019

27 January 2021

4 February 2021

Diabetes, Obesity and Metabolism

12 references

Europe PubMed Central

PMC publication ID

23 August 2017

13 March 2019

14 March 2019

24 March 2019

20 June 2019

5 August 2019

8 September 2019

19 September 2019

7 October 2019

10 October 2019

27 January 2021

4 February 2021

12 Suppl 2

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

99-107

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

copyright license

Creative Commons Attribution 2.5 Generic

11 references

Europe PubMed Central

13 March 2019

Europe PubMed Central

14 March 2019

Europe PubMed Central

24 March 2019

Europe PubMed Central

20 June 2019

Europe PubMed Central

5 August 2019

Europe PubMed Central

8 September 2019

Europe PubMed Central

19 September 2019

Europe PubMed Central

7 October 2019

Europe PubMed Central

10 October 2019

Europe PubMed Central

27 January 2021

Europe PubMed Central

4 February 2021

on focus list of Wikimedia project

0 references

N-glycan structures: recognition and processing in the ER.

1 reference

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Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

1 reference

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Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

1 reference

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6 September 2017

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

1 reference

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Regulation of hepatic lipogenesis by the transcription factor XBP1

1 reference

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6 September 2017

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

1 reference

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Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress

1 reference

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6 September 2017

Proinsulin maturation, misfolding, and proteotoxicity

1 reference

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6 September 2017

Insulin gene mutations as a cause of permanent neonatal diabetes

1 reference

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6 September 2017

The role of p58IPK in protecting the stressed endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

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Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins

1 reference

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6 September 2017

N-glycan processing in ER quality control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Intracellular signaling by the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

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Recognition and delivery of ERAD substrates to the proteasome and alternative paths for cell survival

1 reference

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WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

1 reference

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6 September 2017

Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

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CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

ER stress and the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

The EIF2AK3 gene region and type I diabetes in subjects from South India

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

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Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Oxidative protein folding in eukaryotes: mechanisms and consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

A trip to the ER: coping with stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Roles of CHOP/GADD153 in endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

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Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Eukaryotic translation initiation factors and regulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Orchestrating the unfolded protein response in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Translational control in the endoplasmic reticulum stress response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

1 reference

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6 September 2017

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

1 reference

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6 September 2017

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

1 reference

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6 September 2017

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

WFS1/wolframin mutations, Wolfram syndrome, and associated diseases

1 reference

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6 September 2017

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

6 September 2017

Regulated translation initiation controls stress-induced gene expression in mammalian cells

1 reference

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6 September 2017

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

1 reference

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6 September 2017

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

1 reference

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6 September 2017

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

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6 September 2017

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

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6 September 2017

Identification of novel stress-induced genes downstream of chop

1 reference

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6 September 2017

Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element

1 reference

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6 September 2017

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1 reference

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6 September 2017

DNA damage-inducible transcripts in mammalian cells

1 reference

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6 September 2017

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

1 reference

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6 September 2017

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

1 reference

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1 reference

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14 September 2017

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

1 reference

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14 September 2017

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

1 reference

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23 June 2018

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

1 reference

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23 June 2018

Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance

1 reference

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23 June 2018

Wolfram (DIDMOAD) syndrome.

1 reference

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23 June 2018

Phosphorylation of eukaryotic initiation factor (eIF) 2 alpha and inhibition of eIF-2B in GH3 pituitary cells by perturbants of early protein processing that induce GRP78

1 reference

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23 June 2018

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

1 September 2018

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

1 September 2018

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

1 September 2018

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

1 September 2018

Wolcott-Rallison syndrome: diabetes mellitus and spondyloepiphyseal dysplasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

1 September 2018

Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

3 December 2018

WFS1/wolframin mutations, Wolfram syndrome, and associated diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3127455

3 December 2018

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21029306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wolcott-Rallison syndrome: a case with endocrine and exocrine pancreatic deficiency and pancreatic hypotrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21029306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21029306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A time-dependent phase shift in the mammalian unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21029306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21029306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autopsy findings in the Wolcott-Rallison syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21029306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21029306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1463-1326.2010.01281.X

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

ResearchGate publication ID

0 references

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