(Q37467764)

English

Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB.

scientific article published on December 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB. (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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1 reference

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author name string

Masato Yamazaki

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Hidefumi Fukushima

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Masashi Shin

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Takenobu Katagiri

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Takahiro Doi

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Tetsu Takahashi

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Eijiro Jimi

7

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

language of work or name

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publication date

1 December 2009

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

number of pages

9

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Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

284

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

51

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

35987-35995

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

An update on pharmacogenomics in rheumatoid arthritis with a focus on TNF-blocking agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

New regulators of NF-kappaB in inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

The IkappaB kinase - a bridge between inflammation and cancer

1 reference

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23 August 2017

TNF-mediated inflammatory disease.

1 reference

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23 August 2017

Bone morphogenetic protein signal transduction in bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Smad transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

TNF-R1 signaling: a beautiful pathway

1 reference

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23 August 2017

The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Cytokine pathways and joint inflammation in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

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23 August 2017

Bone: formation by autoinduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Novel regulators of bone formation: molecular clones and activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells

1 reference

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23 August 2017

Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

23 August 2017

TNF-alpha inhibits BMP-induced osteoblast differentiation through activating SAPK/JNK signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

14 September 2017

Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

14 September 2017

Bone morphogenetic protein receptor IB signaling mediates apoptosis independently of differentiation in osteoblastic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

14 September 2017

Identification of a BMP-responsive element in Id1, the gene for inhibition of myogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

28 September 2017

Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

28 September 2017

Inhibition of osteoblast differentiation by tumor necrosis factor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

28 September 2017

Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

28 September 2017

Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

28 September 2017

Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

26 June 2018

Interleukin-1β enhance and tumor necrosis factor-α inhibits bone morphogenetic protein-2-induced alkaline phosphatase activity in MC3T3-E1 osteoblastic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

26 June 2018

Effects of tumor necrosis factor on bone formation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

26 June 2018

Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

26 June 2018

Complications in the use of rhBMP-2 in PEEK cages for interbody spinal fusions

1 reference

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2 September 2018

No effect of bone morphogenetic protein-7 (OP-1) on the incorporation of impacted bone grafts in a realistic acetabular model.

1 reference

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2 September 2018

Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

2 September 2018

Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791026

2 September 2018

Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

1 reference

https://pubmed.ncbi.nlm.nih.gov/19854828

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoinduction by recombinant human bone morphogenetic protein-2 in muscles of non-human primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19854828

12 December 2020

based on heuristic

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Identifiers

10.1074/JBC.M109.070540

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

release_zpyjioeepbgqbmjc3uet6gsctm

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https://api.fatcat.wiki/v0/release/zpyjioeepbgqbmjc3uet6gsctm

24 November 2022

based on heuristic

mapped directly with Wikidata item

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1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

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Europe PubMed Central

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20 August 2017

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