(Q37424811)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

0 references

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Erin G Reed-Geaghan

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Julie C Savage

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Gary E Landreth

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

language of work or name

English

0 references

publication date

1 September 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

11982-11992

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

8 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2778845/fullTextXML

inferred from PubMed Central ID database lookup

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

23 August 2017

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Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice

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Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby acti

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23 August 2017

NADPH oxidase: an update

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Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes

23 August 2017

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Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

23 August 2017

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Assembly and activation of the phagocyte NADPH oxidase. Specific interaction of the N-terminal Src homology 3 domain of p47phox with p22phox is required for activation of the NADPH oxidase

23 August 2017

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Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

23 August 2017

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Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages

23 August 2017

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23 August 2017

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23 August 2017

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Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

23 August 2017

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Bordetella pertussis filamentous hemagglutinin interacts with a leukocyte signal transduction complex and stimulates bacterial adherence to monocyte CR3 (CD11b/CD18).

23 August 2017

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

23 August 2017

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Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

23 August 2017

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Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

23 August 2017

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Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1

23 August 2017

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I kappa B: a specific inhibitor of the NF-kappa B transcription factor

23 August 2017

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

23 August 2017

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Lipopolysaccharide-binding protein- and CD14-dependent activation of mitogen-activated protein kinase p38 by lipopolysaccharide in human neutrophils is associated with priming of respiratory burst.

23 August 2017

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Modulation of lipopolysaccharide-induced monocyte activation by heparin-binding protein and fucoidan

14 September 2017

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Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells

14 September 2017

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MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis

14 September 2017

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Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line

14 September 2017

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Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

14 September 2017

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A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites

14 September 2017

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Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier

14 September 2017

1 reference

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Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1.

14 September 2017

1 reference

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Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

14 September 2017

1 reference

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Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses

14 September 2017

1 reference

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Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production

14 September 2017

1 reference

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Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.

14 September 2017

1 reference

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CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans

14 September 2017

1 reference

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Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B.

28 September 2017

1 reference

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Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

28 September 2017

1 reference

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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

28 September 2017

1 reference

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Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins

28 September 2017

1 reference

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Alzheimer's beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia

28 September 2017

1 reference

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The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors

28 September 2017

1 reference

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Microglia derived from aging mice exhibit an altered inflammatory profile.

28 September 2017

1 reference

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Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.

26 June 2018

1 reference

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beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease

26 June 2018

1 reference

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Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

26 June 2018

1 reference

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Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

GM1 induces p38 and microtubule dependent ramification of rat primary microglia in vitro

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Rac2 GTPase activation by angiotensin II is modulated by Ca2+/calcineurin and mitogen-activated protein kinases in human neutrophils

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Screening of innate immune receptors in neurodegenerative diseases: a similar pattern.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Evidence that aging and amyloid promote microglial cell senescence

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Regulation of phagosome maturation by signals from toll-like receptors

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

High-yield isolation of murine microglia by mild trypsinization.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

The LPS receptor (CD14) links innate immunity with Alzheimer's disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

P38 MAP kinase is activated at early stages in Alzheimer's disease brain

2 September 2018

1 reference

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Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Scavenger receptor-like receptors for the binding of lipopolysaccharide and lipoteichoic acid to liver endothelial and Kupffer cells

2 September 2018

1 reference

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Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

p38 kinase is activated in the Alzheimer's disease brain

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Lipopolysaccharide structure influences the macrophage response via CD14-independent and CD14-dependent pathways

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia

2 September 2018

1 reference

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Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778845

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

2 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Microassays for superoxide and hydrogen peroxide production and nitroblue tetrazolium reduction using an enzyme immunoassay microplate reader

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Signal transduction by immunoglobulin Fc receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Roles of p38 MAPK, PKC and PI3-K in the signaling pathways of NADPH oxidase activation and phagocytosis in bovine polymorphonuclear leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Intracellular pathways involved in TNF-alpha and superoxide anion release by Abeta(1-42)-stimulated primary human macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Priming of monocyte respiratory burst by beta-amyloid fragment (25-35)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19776284

12 December 2020

10.1523/JNEUROSCI.3158-09.2009

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19776284%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

19776284

1 reference