(Q37202023)

18 August 2017

IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion (English)

1 reference

18 August 2017

0 references

8

P Miossec

0 references

author name string

E Lubberts

1

1 reference

18 August 2017

L A Joosten

2

1 reference

18 August 2017

M Chabaud

3

1 reference

18 August 2017

L van Den Bersselaar

4

1 reference

18 August 2017

B Oppers

5

1 reference

18 August 2017

C J Coenen-De Roo

6

1 reference

18 August 2017

C D Richards

7

1 reference

18 August 2017

W B van Den Berg

9

1 reference

18 August 2017

language of work or name

English

0 references

publication date

1 June 2000

1 reference

Journal of Clinical Investigation

18 August 2017

1 reference

18 August 2017

105

1 reference

18 August 2017

12

1 reference

18 August 2017

1697-1710

1 reference

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Advances in bone biology: the osteoclast

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Increased type I collagen degradation correlates with disease severity in rheumatoid arthritis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Cells of bone: proliferation, differentiation, and hormonal regulation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Modulation of osteoclast differentiation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Autoimmunity to type II collagen an experimental model of arthritis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Osteoclast-like cells in murine collagen induced arthritis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Th1/Th2 cytokine balance in arthritis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Inhibitory effect of interleukin-4 on osteoclast-like cell formation in mouse bone marrow culture.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

The erosive front: a topographic study of the junction between the pannus and the subchondral plate in the macerated rheumatoid metacarpal head

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

IL-6 is produced by osteoblasts and induces bone resorption

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment alone

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

An update on interleukin-4 and its receptor

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Interleukin-4 inhibits bone resorption and acutely increases cytosolic Ca2+ in murine osteoclasts

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=378501

Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: assessment with serum type I collagen breakdown products

20 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Elevated procollagen type I carboxyterminal propeptide production in cultured scleroderma fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Immunisation against heterologous type II collagen induces arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Quantitative analysis of cytokine gene expression in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Interleukin-4 as a potent inhibitor of bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Increased osteoclast development after estrogen loss: mediation by interleukin-6

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin-4 in an ex vivo model of rheumatoid synovitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Quantification of mRNA levels in joint capsule and articular cartilage of the murine knee joint by RT-PCR: kinetics of stromelysin and IL-1 mRNA levels during arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Restricted cytokine expression in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Effects of interleukin-4 on the formation of macrophages and osteoclast-like cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Interleukin-4 inhibits bone resorption through an effect on osteoclasts and proinflammatory cytokines in an ex vivo model of bone resorption in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Etretinate administration reduces serum propeptide of type I procollagen level in patients with psoriasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Increased type I collagen degradation in early rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Measurement of bone degradation products in serum using antibodies reactive with an isomerized form of an 8 amino acid sequence of the C-telopeptide of type I collagen

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Molecular biology of cartilage and bone destruction

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Joint inflammation and cartilage destruction may occur uncoupled

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Osteoclasts and effects of interleukin 4 in development of chronic osteomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10862785

12 December 2020

Identifiers

DOI

10.1172/JCI7739

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

10862785

1 reference