(Q36895405)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661163%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

review article

1 reference

title

Hypoxia, glucose metabolism and the Warburg's effect (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661163%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

0 references

1

1 reference

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2 January 2020

author name string

Jaime Caro

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661163%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

publication date

1 June 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661163%20AND%20SRC:MED&resulttype=core&format=json

Journal of Bioenergetics and Biomembranes

2 January 2020

published in

1 reference

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2 January 2020

volume

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661163%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

issue

3

1 reference

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2 January 2020

page(s)

223-229

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

2 January 2020

cites work

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12 December 2020

On respiratory impairment in cancer cells

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12 December 2020

An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis.

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12 December 2020

Hypoxia and the regulation of gene expression

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12 December 2020

Subunit composition, regulatory properties, and phosphorylation of phosphofructokinase from human gliomas.

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12 December 2020

Why do cancers have high aerobic glycolysis?

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https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Activation of the HIF pathway in cancer

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https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Signalling hypoxia by HIF hydroxylases

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https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase

1 reference

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12 December 2020

Control of phosphofructokinase by fructose 2,6-bisphosphate in B-lymphocytes and B-chronic lymphocytic leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Cloning and expression of a catalytic core bovine brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Glycolytic enzyme activities in breast cancer metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Cooperation and competition in the evolution of ATP-producing pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Fructose 2,6-bisphosphate and the control of glycolysis by growth factors, tumor promoters and oncogenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Molecular pathways in renal cell carcinoma--rationale for targeted treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

The antioxidant function of the p53 tumor suppressor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Insulin induces PFKFB3 gene expression in HT29 human colon adenocarcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/17661163

1 reference

12 December 2020

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Live or let die: the cell's response to p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Ras transformation requires metabolic control by 6-phosphofructo-2-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Cancer metabolism: facts, fantasy, and fiction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Cancer's molecular sweet tooth and the Warburg effect.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

HIF hydroxylation and cellular oxygen sensing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Cytokines and hormones in the regulation of hypoxia inducible factor-1alpha (HIF-1alpha).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Phosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

The HIF pathway in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

HIF, a missing link between metabolism and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Phorbol 12-myristate 13-acetate and insulin increase the concentration of fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

The role of the hypoxia-inducible factor in tumor metabolism growth and invasion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Hypoxia regulation of gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Oncogenic alterations of metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Regulation of 6-phosphofructo-1-kinase activity in ras-transformed rat-1 fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Glycolysis inhibition for anticancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

The Pasteur effect and the relations between respiration and fermentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

The AMP-activated protein kinase pathway--new players upstream and downstream.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Fructose 2,6-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

p53 regulates mitochondrial respiration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase expression in rat brain during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Development of novel therapeutic strategies that target HIF-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

HIF-1 and tumor progression: pathophysiology and therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Glycolytic enzymes can modulate cellular life span

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Mitochondria and cancer: Warburg addressed

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

Was Warburg right? Or was it that simple?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17661163

12 December 2020

10.1007/S10863-007-9080-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17661163%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference