(Q36836677)

English

Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.

scientific article published on 29 January 2013

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scholarly article

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23 February 2020

Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas (English)

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23 February 2020

Cristina Montero-Conde

1

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23 February 2020

Sergio Ruiz-Llorente

2

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23 February 2020

Jeffrey A Knauf

4

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23 February 2020

author name string

Jose M Dominguez

3

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23 February 2020

Agnes Viale

5

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23 February 2020

Eric J Sherman

6

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23 February 2020

Mabel Ryder

7

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23 February 2020

Ronald A Ghossein

8

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23 February 2020

Neal Rosen

9

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23 February 2020

James A Fagin

10

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23 February 2020

publication date

29 January 2013

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23 February 2020

Cancer Discovery

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23 February 2020

3

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23 February 2020

5

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23 February 2020

520-533

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23 February 2020

Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma

1 reference

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29 September 2017

Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas

1 reference

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29 September 2017

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

1 reference

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29 September 2017

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

1 reference

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29 September 2017

EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib

1 reference

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29 September 2017

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

1 reference

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29 September 2017

Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements

1 reference

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29 September 2017

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

1 reference

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29 September 2017

Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers

1 reference

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29 September 2017

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

1 reference

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29 September 2017

Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations

1 reference

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29 September 2017

Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3651738

29 September 2017

Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice

1 reference

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29 September 2017

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

1 reference

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29 September 2017

Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

1 reference

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29 September 2017

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

1 reference

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29 September 2017

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

1 reference

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29 September 2017

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

1 reference

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29 September 2017

ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells

1 reference

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29 September 2017

RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models

1 reference

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29 September 2017

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells

1 reference

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29 September 2017

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

1 reference

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29 September 2017

Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.

1 reference

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29 September 2017

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

1 reference

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29 September 2017

Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification

1 reference

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Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex

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29 September 2017

BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications

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The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

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27 June 2018

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma

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12 December 2020

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10.1158/2159-8290.CD-12-0531

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23 February 2020

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23 February 2020

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23 February 2020

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