(Q36269671)

13 August 2017

1 reference

title

Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches (English)

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13 August 2017

David A D'Alessio

1

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13 August 2017

Torsten P Vahl

series ordinal

2

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13 August 2017

publication date

1 October 2005

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13 August 2017

published in

Current diabetes report

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13 August 2017

volume

5

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13 August 2017

issue

5

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13 August 2017

page(s)

346-352

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Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man

13 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11892-005-0092-2

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Enhancing Incretin Action for the Treatment of Type 2 Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Normalization of insulin responses to glucose by overnight infusion of glucagon-like peptide 1 (7-36) amide in patients with NIDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Glucagon-like peptide-1 7-36: a physiological incretin in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effects of glucagon-like peptide-1(7-36)amide on motility and sensation of the proximal stomach in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

The glucagon-like peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

A role for glucagon-like peptide-1 in the central regulation of feeding

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Extrapancreatic effects of GIP and GLP-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16188169

12 December 2020

10.1007/S11892-005-0092-2

Identifiers

DOI

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13 August 2017

1 reference