(Q36063511)

11 August 2017

Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity (English)

1 reference

11 August 2017

1 reference

H Kawasome

1

1 reference

11 August 2017

P Papst

2

1 reference

11 August 2017

S Webb

3

1 reference

11 August 2017

G M Keller

4

1 reference

11 August 2017

G L Johnson

5

1 reference

11 August 2017

E W Gelfand

6

1 reference

11 August 2017

N Terada

7

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11 August 2017

language of work or name

English

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publication date

1 April 1998

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11 August 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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11 August 2017

95

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11 August 2017

9

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11 August 2017

5033-5038

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The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin-sensitive phosphorylation of ribosomal protein S17 by p70 S6 kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

A signaling pathway to translational control

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Nuclear localization of p85s6k: functional requirement for entry into S phase.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Control of p70 s6 kinase by kinase activity of FRAP in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Localization of the target site for translational regulation of the L11 operon and direct evidence for translational coupling in Escherichia coli

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Identification and characterization of a mitogen-activated S6 kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Identification of a ribosomal protein S6 kinase regulated by transformation and growth-promoting stimuli

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Unmasking a growth factor/oncogene-activated S6 phosphorylation cascade

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Production of homozygous mutant ES cells with a single targeting construct

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Protein Phosphorylation in Translational Control

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20208

p70s6k function is essential for G1 progression

21 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.95.9.5033

Insulin stimulates the translation of ribosomal proteins and the transcription of rDNA in mouse myoblasts

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560223

12 December 2020

Modulation of transcription of rRNA genes by rapamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560223

12 December 2020

EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560223

12 December 2020

Purification of a hepatic S6 kinase from cycloheximide-treated Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560223

12 December 2020

Proteins of small subunits of rat liver ribosomes that interact with poly(U). I. Effects of preincubation of poly(U) with 40 S subunits on the interactions of 40 S subunit proteins with aurintricarboxylic acid and with N,N'-p-phenylenedimaleimide

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560223

12 December 2020

Immunochemical detection of proteins in the small subunit of rat liver ribosomes involved in binding of the ternary initiation complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560223

12 December 2020

Protein topography of the 40 S ribosomal subunit from rabbit reticulocytes shown by cross-linking with 2-iminothiolane

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560223

12 December 2020

Identifiers

DOI

10.1073/PNAS.95.9.5033

1 reference

11 August 2017

0 references

1 reference

11 August 2017

PubMed publication ID

9560223

1 reference