(Q36002359)

11 August 2017

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title

The role of small RNAs in human diseases: potential troublemaker and therapeutic tools (English)

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11 August 2017

Huan Gong

1

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11 August 2017

Chang-Mei Liu

series ordinal

2

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11 August 2017

De-Pei Liu

series ordinal

3

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11 August 2017

Chih-Chuan Liang

series ordinal

4

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11 August 2017

publication date

1 May 2005

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Medicinal Research Reviews

11 August 2017

published in

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11 August 2017

volume

25

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11 August 2017

issue

3

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11 August 2017

page(s)

361-381

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Cloned zebrafish by nuclear transfer from long-term-cultured cells

11 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FMED.20023

Antisense-RNA regulation and RNA interference

21 January 2018

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Crossref

https://api.crossref.org/works/10.1002%2FMED.20023

Reduced accumulation of specific microRNAs in colorectal neoplasia

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Small interfering RNA urokinase silencing inhibits invasion and migration of human hepatocellular carcinoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Numerous microRNPs in neuronal cells containing novel microRNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Specific inhibition of bcr-abl gene expression by small interfering RNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Modulation of HIV-1 replication by RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

RNA interference is mediated by 21- and 22-nucleotide RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

RNA silencing in plants--defense and counterdefense

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Role for a bidentate ribonuclease in the initiation step of RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

The microRNAs of Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

An extensive class of small RNAs in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

An expanding universe of noncoding RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Protection against lethal influenza virus challenge by RNA interference in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Identification of tissue-specific microRNAs from mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Inhibition of hepatitis B virus expression and replication by RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

The microRNA world: small is mighty

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

microRNAs: tiny regulators with great potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Stable suppression of tumorigenicity by virus-mediated RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Identification of novel genes coding for small expressed RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Inhibition of influenza virus production in virus-infected mice by RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Short interfering RNA confers intracellular antiviral immunity in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

siRNA-directed inhibition of HIV-1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

MicroRNAs modulate hematopoietic lineage differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

RNA interference: the fragile X syndrome connection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/15637700

1 reference

12 December 2020

Why do miRNAs live in the miRNP?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Nuclear export of microRNA precursors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

RNA silencing: the genome's immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Establishment of conditional vectors for hairpin siRNA knockdowns

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/15637700

1 reference

12 December 2020

Loss of heterozygosity at 13q14 and 13q21 in high grade, high stage prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Inhibition of severe acute respiratory syndrome virus replication by small interfering RNAs in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Role of microRNAs in plant and animal development

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

The nuclear RNase III Drosha initiates microRNA processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Interfering with disease: opportunities and roadblocks to harnessing RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Vertebrate microRNA genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

RNA interference of HIV replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Two classes of short interfering RNA in RNA silencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

CRE recombinase-inducible RNA interference mediated by lentiviral vectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Inhibition of HBV replication by siRNA in a stable HBV-producing cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Inhibition of hepatitis B virus in mice by RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

A system for stable expression of short interfering RNAs in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/15637700

1 reference

12 December 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Allele-specific silencing of dominant disease genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Inducible, reversible, and stable RNA interference in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

A microRNA in a multiple-turnover RNAi enzyme complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15637700

12 December 2020

Identifiers

DOI

10.1002/MED.20023

1 reference

11 August 2017

0 references

1 reference