(Q35983181)

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Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism

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Europe PubMed Central

PMC publication ID

11 August 2017

Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism (English)

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Europe PubMed Central

PMC publication ID

11 August 2017

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author name string

Gerald J Atkins

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Peter S Rowe

2

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Europe PubMed Central

PMC publication ID

11 August 2017

Hui P Lim

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Katie J Welldon

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Renee Ormsby

5

1 reference

Europe PubMed Central

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11 August 2017

Asiri R Wijenayaka

6

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Lesya Zelenchuk

7

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Andreas Evdokiou

8

1 reference

Europe PubMed Central

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11 August 2017

David M Findlay

9

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Europe PubMed Central

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11 August 2017

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1 July 2011

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Europe PubMed Central

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11 August 2017

Journal of Bone and Mineral Research

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Europe PubMed Central

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11 August 2017

26

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Europe PubMed Central

PMC publication ID

11 August 2017

7

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Europe PubMed Central

PMC publication ID

11 August 2017

1425-1436

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Europe PubMed Central

PMC publication ID

11 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3358926/fullTextXML

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Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women

1 reference

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2 October 2017

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

1 reference

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2 October 2017

Regulation of circulating sclerostin levels by sex steroids in women and in men.

1 reference

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2 October 2017

Wnt modulators in the biotech pipeline

1 reference

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2 October 2017

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo

1 reference

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2 October 2017

Phosphorylation-dependent inhibition of mineralization by osteopontin ASARM peptides is regulated by PHEX cleavage

1 reference

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2 October 2017

Novel regulators of Fgf23 expression and mineralization in Hyp bone

1 reference

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2 October 2017

The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles

1 reference

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2 October 2017

Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts

1 reference

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2 October 2017

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Matrix mineralization as a trigger for osteocyte maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis

1 reference

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2 October 2017

A new paradigm in the treatment of osteoporosis: Wnt pathway proteins and their antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Update in osteoporosis and metabolic bone disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Wnt signaling: a key regulator of bone mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Mechanism by which MLO-A5 late osteoblasts/early osteocytes mineralize in culture: similarities with mineralization of lamellar bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

1 reference

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2 October 2017

E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Regulation of bone mass by Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins

1 reference

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2 October 2017

The wrickkened pathways of FGF23, MEPE and PHEX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

MEPE has the properties of an osteoblastic phosphatonin and minhibin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family

1 reference

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2 October 2017

Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Role of the mouse ank gene in control of tissue calcification and arthritis

1 reference

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2 October 2017

Further characterization of cells expressing STRO-1 in cultures of adult human bone marrow stromal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Intrinsic mineralization defect in Hyp mouse osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

2 October 2017

Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Pathogenic role of Fgf23 in Hyp mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

The proliferation and phenotypic expression of human osteoblasts on tantalum metal.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

RANKL expression is related to the differentiation state of human osteoblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Inhibition of MEPE cleavage by Phex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete developmental stages in primary cultures of human bone cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358926

24 September 2018

Human bone cellsin vitro

2 references

https://api.crossref.org/works/10.1002%2FJBMR.345

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/21312267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sclerostin in Mineralized Matrices and van Buchem Disease

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.345

21 January 2018

Temporal regulation of hyaluronan and proteoglycan metabolism by human bone cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21312267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of intermittent parathyroid hormone (PTH) administration on SOST mRNA and protein in rat bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/21312267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/21312267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/JBMR.345

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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