(Q35915726)

English

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

scientific article published on 19 January 2012

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22262760%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma (English)

1 reference

Europe PubMed Central

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20 January 2020

multiple myeloma

1 reference

based on heuristic

inferred from title

pharmacokinetics

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based on heuristic

inferred from title

pharmacodynamics

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based on heuristic

inferred from title

3

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20 January 2020

Kenneth C. Anderson

17

object named as

Kenneth C Anderson

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20 January 2020

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Loredana Santo

1

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20 January 2020

Teru Hideshima

2

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20 January 2020

Jen-Chieh Tseng

4

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20 January 2020

David Tamang

5

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20 January 2020

Min Yang

6

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20 January 2020

Matthew Jarpe

7

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20 January 2020

John H van Duzer

8

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20 January 2020

Ralph Mazitschek

9

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20 January 2020

Walter C Ogier

10

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20 January 2020

Diana Cirstea

11

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20 January 2020

Scott Rodig

12

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20 January 2020

Homare Eda

13

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20 January 2020

Tyler Scullen

14

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20 January 2020

Miriam Canavese

15

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20 January 2020

James Bradner

16

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20 January 2020

Simon S Jones

18

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20 January 2020

Noopur Raje

19

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20 January 2020

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19 January 2012

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20 January 2020

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20 January 2020

119

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20 January 2020

11

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20 January 2020

2579-2589

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20 January 2020

describes a project that uses

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11 June 2022

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based on heuristic

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Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide

1 reference

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11 July 2018

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents

1 reference

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11 July 2018

Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells

1 reference

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11 July 2018

The histone deacetylase inhibitor LBH589 enhances the anti-myeloma effects of chemotherapy in vitro and in vivo

1 reference

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11 July 2018

Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.

1 reference

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11 July 2018

Combined proteasome and histone deacetylase inhibition: A promising synergy for patients with relapsed/refractory multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337713

11 July 2018

HDAC inhibition synergistically enhances alkylator-induced DNA damage responses and apoptosis in multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337713

11 July 2018

Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337713

11 July 2018

Histone deacetylases and epigenetic therapies of hematological malignancies

1 reference

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11 July 2018

Chemical phylogenetics of histone deacetylases

1 reference

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11 July 2018

AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.

1 reference

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11 July 2018

Vorinostat enhances the antimyeloma effects of melphalan and bortezomib

1 reference

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11 July 2018

Preclinical antileukemia activity of JNJ-26481585, a potent second-generation histone deacetylase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337713

11 July 2018

Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma

1 reference

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11 July 2018

Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib

1 reference

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11 July 2018

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

1 reference

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11 July 2018

Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma

1 reference

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11 July 2018

Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

1 reference

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11 July 2018

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

1 reference

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11 July 2018

Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy

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11 July 2018

From the bench to the bedside: emerging new treatments in multiple myeloma

1 reference

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11 July 2018

HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination

1 reference

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11 July 2018

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

1 reference

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11 July 2018

Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells

1 reference

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11 July 2018

Functions of site-specific histone acetylation and deacetylation

1 reference

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11 July 2018

The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance.

1 reference

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11 July 2018

Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

1 reference

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Targeting histone deacetylase in cancer therapy

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Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

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Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

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11 July 2018

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

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11 July 2018

A phase 2 study of bortezomib in relapsed, refractory myeloma

1 reference

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11 July 2018

Molecular mechanisms of novel therapeutic approaches for multiple myeloma

1 reference

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11 July 2018

Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma

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24 September 2018

Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.

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24 September 2018

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

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24 September 2018

Molecular sequelae of histone deacetylase inhibition in human malignant B cells

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24 September 2018

Proteasome and HDAC: who's zooming who?

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2011-10-387365

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22262760%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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20 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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20 January 2020

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