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Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
scientific article published on February 1998
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scholarly article
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stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
title
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
author
Andrew W. Roberts
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
author name string
S Kimura
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
D Metcalf
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
W S Alexander
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
language of work or name
English
0 references
publication date
1 February 1998
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
published in
Proceedings of the National Academy of Sciences of the United States of America
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
volume
95
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
issue
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
page(s)
1195-1200
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
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Europe PubMed Central
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC18717/fullTextXML
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cites work
Murine hematopoietic stem cells committed to macrophage/dendritic cell formation: stimulation by Flk2-ligand with enhancement by regulators using the gp130 receptor chain
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Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating f
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11 July 2018
Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer
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11 July 2018
Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin- primitive progenitor cells
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Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice.
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11 July 2018
Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice
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11 July 2018
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
1 reference
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PubMed Central
reference URL
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11 July 2018
Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
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11 July 2018
Differentiation and proliferation of hematopoietic stem cells
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PubMed Central
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11 July 2018
Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
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11 July 2018
Thrombocytopenia in c-mpl-deficient mice
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11 July 2018
Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system.
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11 July 2018
Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
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11 July 2018
Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor.
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11 July 2018
Y-encoded, species-specific DNA in mice: evidence that the Y chromosome exists in two polymorphic forms in inbred strains
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11 July 2018
Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.
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Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure
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11 July 2018
Quantitative responsiveness of murine hemopoietic populations in vitro and in vivo to recombinant multi-CSF (IL-3).
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11 July 2018
MPLV: a retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice
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11 July 2018
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy
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Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies: influence of colony-stimulating factors
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Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+CD38- bone marrow cells with multilineage potential at the single-cell level: key role of thrombopoietin
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Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
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Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation
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21 January 2018
Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Recombinant human c-Mpl ligand (thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Competitive repopulation: a new assay for long-term stem cell functional capacity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Functional isolation and characterization of human hematopoietic stem cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9448308
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1073/PNAS.95.3.1195
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
ADS bibcode
1998PNAS...95.1195K
0 references
PMC publication ID
18717
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
PubMed publication ID
9448308
1 reference
stated in
Europe PubMed Central
PMC publication ID
18717
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448308%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
ResearchGate publication ID
13783020
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