(Q35745144)

10 August 2017

title

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. (English)

1 reference

10 August 2017

Gary G Chiang

6

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Peter J. Brown

object named as

Peter J Brown

5

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Cheryl Arrowsmith

object named as

Cheryl H Arrowsmith

4

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author name string

Ramzi F Sweis

1

1 reference

10 August 2017

Zhi Wang

2

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10 August 2017

Mikkel Algire

3

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10 August 2017

Jun Guo

7

1 reference

10 August 2017

Clarissa G Jakob

8

1 reference

10 August 2017

Steven Kennedy

9

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10 August 2017

Fengling Li

10

1 reference

10 August 2017

David Maag

11

1 reference

10 August 2017

Bailin Shaw

12

1 reference

10 August 2017

Nirupama B Soni

13

1 reference

10 August 2017

Masoud Vedadi

14

1 reference

10 August 2017

William N Pappano

15

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10 August 2017

publication date

29 April 2015

1 reference

ACS Medicinal Chemistry Letters

10 August 2017

published in

1 reference

10 August 2017

volume

6

1 reference

10 August 2017

issue

6

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10 August 2017

page(s)

695-700

1 reference

LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.

10 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Structural basis of substrate methylation and inhibition of SMYD2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Small-Molecule Ligands of Methyl-Lysine Binding Proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Methylation of the retinoblastoma tumor suppressor by SMYD2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Repression of p53 activity by Smyd2-mediated methylation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

SMYD2 is highly expressed in pediatric acute lymphoblastic leukemia and constitutes a bad prognostic factor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Substituent effects on carbocation stability: the pK(R) for p-quinone methide

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4468393

Biochemical characterization of human SET and MYND domain-containing protein 2 methyltransferase

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26101576

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACSMEDCHEMLETT.5B00124

1 reference

10 August 2017

1 reference

10 August 2017

1 reference