(Q35377867)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

title

Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

0 references

1 reference

5

Leppla SH

2 references

PubMed publication ID

7806387

8 August 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

2

Klimpel KR

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

author name string

Gordon VM

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

Arora N

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

Henderson MA

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

language of work or name

English

0 references

publication date

1 January 1995

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

January 1995

0 references

published in

Infection and Immunity

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

volume

63

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

page(s)

82-87

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7806387%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

26 October 2019

NCI-CHOdeltafurin

0 references

cites work

Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Evidence for involvement of furin in cleavage and activation of diphtheria toxin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

A furin-defective cell line is able to process correctly the gp160 of human immunodeficiency virus type 1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Strains of CHO-K1 cells resistant to Pseudomonas exotoxin A and cross-resistant to diphtheria toxin and viruses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Domain II mutants of Pseudomonas exotoxin deficient in translocation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Mammalian subtilisins: the long-sought dibasic processing endoproteases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

A mutant CHO-K1 strain with resistance to Pseudomonas exotoxin A and alphaviruses fails to cleave Sindbis virus glycoprotein PE2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Characterization of a cellular protease that cleaves Pseudomonas exotoxin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Consensus sequence for precursor processing at mono-arginyl sites. Evidence for the involvement of a Kex2-like endoprotease in precursor cleavages at both dibasic and mono-arginyl sites

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172960

Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4

12 July 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

Role of beta-turn in proteolytic processing of peptide hormone precursors at dibasic sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

Selection of Pseudomonas exotoxin-resistant cells with altered expression of alpha 2MR/LRP

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

Specific cleavage of diphtheria toxin by human urokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

Production and purification of anthrax toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

Translocation of diphtheria toxin A-fragment to the cytosol. Role of the site of interfragment cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020

A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/7806387

12 December 2020