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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.
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Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
title
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
author
Maureen Murphy
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
Ronald M. Evans
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
author name string
J Ahn
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2
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stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
K K Walker
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
W H Hoffman
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4
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
A J Levine
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
D L George
series ordinal
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
publication date
1 October 1999
1 reference
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Europe PubMed Central
PMC publication ID
317076
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
published in
Genes & Development
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
volume
13
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
issue
19
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
page(s)
2490-2501
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
cites work
Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
DNA damage increases sensitivity to vinca alkaloids and decreases sensitivity to taxanes through p53-dependent repression of microtubule-associated protein 4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
c-Myc target gene specificity is determined by a post-DNAbinding mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
The complexity of p53 modulation: emerging patterns from divergent signals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
DNA damage activates p53 through a phosphorylation-acetylation cascade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
The histone acetylase PCAF is a nuclear receptor coactivator.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Rb interacts with histone deacetylase to repress transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
The polyproline region of p53 is required to activate apoptosis but not growth arrest.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Recruitment of p300/CBP in p53-dependent signal pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Binding and modulation of p53 by p300/CBP coactivators
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Histone deacetylase activity is required for full transcriptional repression by mSin3A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
p53, the cellular gatekeeper for growth and division
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
The p53 response to ionising radiation in adult and developing murine tissues.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Identification of a novel p53 functional domain that is necessary for efficient growth suppression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Wild-type p53 negatively regulates the expression of a microtubule-associated protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
p53: puzzle and paradigm
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Life, death, and the pursuit of apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
The p53-mdm-2 autoregulatory feedback loop
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Human TAFII31 protein is a transcriptional coactivator of the p53 protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
13 July 2018
The p53 tumor suppressor inhibits transcription of the TATA-less mouse DP1 promoter.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
26 September 2018
Induction of apoptosis in HeLa cells by trans-activation-deficient p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317076
retrieved
26 September 2018
An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutants
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10521394
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Distinct regions of p53 have a differential role in transcriptional activation and repression functions
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10521394
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/GAD.13.19.2490
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
PMC publication ID
317076
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
PubMed publication ID
10521394
1 reference
stated in
Europe PubMed Central
PMC publication ID
317076
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10521394%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
ResearchGate publication ID
12779921
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