(Q35166828)

6 August 2017

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title

CpG motifs: the active ingredient in bacterial extracts? (English)

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6 August 2017

1

Arthur M Krieg

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6 August 2017

language of work or name

English

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publication date

1 July 2003

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6 August 2017

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6 August 2017

volume

9

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6 August 2017

issue

7

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6 August 2017

page(s)

831-835

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Coley's toxins, tumor necrosis factor and cancer research: a historical perspective

6 August 2017

cites work

1 reference

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7 January 2021

Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

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7 January 2021

Innate immune recognition

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7 January 2021

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

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7 January 2021

A Toll-like receptor recognizes bacterial DNA

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7 January 2021

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

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7 January 2021

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

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7 January 2021

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

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7 January 2021

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

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7 January 2021

Dendritic cell maturation and subsequent enhanced T-cell stimulation induced with the novel synthetic immune response modifier R-848

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7 January 2021

Adjuvant activities of immune response modifier R-848: comparison with CpG ODN

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7 January 2021

Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

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7 January 2021

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

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7 January 2021

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

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7 January 2021

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

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7 January 2021

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

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7 January 2021

Immunostimulatory DNA sequences influence the course of adjuvant arthritis

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https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

CpG motifs in bacterial DNA trigger direct B-cell activation

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https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

CpG motifs in bacterial DNA and their immune effects

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7 January 2021

Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells

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7 January 2021

Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins

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7 January 2021

Immune recognition of foreign DNA: a cure for bioterrorism?

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7 January 2021

Postexposure prophylaxis against prion disease with a stimulator of innate immunity

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7 January 2021

CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma

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7 January 2021

Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines.

1 reference

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7 January 2021

CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity

1 reference

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7 January 2021

Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model.

1 reference

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7 January 2021

Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs.

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7 January 2021

NK- and CD8(+) T cell-mediated eradication of established tumors by peritumoral injection of CpG-containing oligodeoxynucleotides.

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7 January 2021

Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity

1 reference

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7 January 2021

CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans

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https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys

1 reference

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7 January 2021

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants

1 reference

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7 January 2021

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1 reference

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7 January 2021

Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides

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7 January 2021

Vaccination with tumor peptide in CpG adjuvant protects via IFN-gamma-dependent CD4 cell immunity.

1 reference

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7 January 2021

CpG are efficient adjuvants for specific CTL induction against tumor antigen-derived peptide

1 reference

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7 January 2021

Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients

1 reference

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7 January 2021

Combined dendritic cell- and CpG oligonucleotide-based immune therapy cures large murine tumors that resist chemotherapy

1 reference

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7 January 2021

Prevention of spontaneous mammary adenocarcinoma in HER-2/neu transgenic mice by foreign DNA

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7 January 2021

Antisense c-myc and immunostimulatory oligonucleotide inhibition of tumorigenesis in a murine B-cell lymphoma transplant model

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7 January 2021

Avoiding tolerance against prostatic antigens with subdominant peptide epitopes

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7 January 2021

Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo

1 reference

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7 January 2021

https://api.crossref.org/works/10.1038%2FNM0703-831

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7 January 2021

Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

A hepatitis B vaccine formulated with a novel adjuvant system

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Uptake of Apoptotic Antigen-Coupled Cells by Lymphoid Dendritic Cells and Cross-Priming of CD8+ T Cells Produce Active Immune Unresponsiveness

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Synergy between CpG- or non-CpG DNA and specific antigen for B cell activation

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

A role for Toll in autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Do DNA vaccines induce autoimmune disease?

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

The molecular basis for the lack of immunostimulatory activity of vertebrate DNA.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-831

7 January 2021

Identifiers

DOI

10.1038/NM0703-831

1 reference

6 August 2017

1 reference