(Q35135529)

6 August 2017

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title

Intrinsic and extrinsic uncoupling of oxidative phosphorylation (English)

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6 August 2017

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Bernhard Kadenbach

1

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6 August 2017

language of work or name

English

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publication date

1 June 2003

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Biochimica et Biophysica Acta

6 August 2017

published in

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6 August 2017

volume

1604

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6 August 2017

issue

2

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6 August 2017

page(s)

77-94

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Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria

6 August 2017

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Human aging is associated with stochastic somatic mutations of mitochondrial DNA.

7 January 2021

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Uncouplers of oxidative phosphorylation

7 January 2021

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7 January 2021

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A threshold membrane potential accounts for controversial effects of fatty acids on mitochondrial oxidative phosphorylation

7 January 2021

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The physiological significance of mitochondrial proton leak in animal cells and tissues

7 January 2021

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Thermogenic mechanisms in brown fat

7 January 2021

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Mechanism and evolution of the uncoupling protein of brown adipose tissue

7 January 2021

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Mitochondrial transport of cations: channels, exchangers, and permeability transition.

7 January 2021

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Chimers of two fused ADP/ATP carrier monomers indicate a single channel for ADP/ATP transport

7 January 2021

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Expression in Escherichia coli, functional characterization, and tissue distribution of isoforms A and B of the phosphate carrier from bovine mitochondria

7 January 2021

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Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria

7 January 2021

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The stoichiometry of H+ pumping in cytochrome oxidase and the mechanism of uncoupling

7 January 2021

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7 January 2021

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The optimal efficiency and the economic degrees of coupling of oxidative phosphorylation.

7 January 2021

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The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution.

7 January 2021

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Effect of funiculosin and antimycin A on the redox-driven H+-pumps in mitochondria: on the nature of "leaks'.

7 January 2021

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Molecular slipping in redox and ATPase H+ pumps

7 January 2021

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Intrinsic uncoupling of mitochondrial proton pumps. 1. Non-ohmic conductance cannot account for the nonlinear dependence of static head respiration on delta microH.

7 January 2021

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7 January 2021

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Rat mitochondrial glycerol-3-phosphate dehydrogenase gene: multiple promoters, high levels in brown adipose tissue, and tissue-specific regulation by thyroid hormone

7 January 2021

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Comparison of energy-transducing capabilities of the two- and three-subunit cytochromes aa3 from Paracoccus denitrificans and the 13-subunit beef heart enzyme

7 January 2021

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Potentiometric and spectral studies with the two-subunit cytochrome aa3 from Paracoccus denitrificans. Comparison with the 13-subunit beef heart enzyme

7 January 2021

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On the function of multiple subunits of cytochrome c oxidase from higher eukaryotes

7 January 2021

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Regulation of the H+/e- stoichiometry of cytochrome c oxidase from bovine heart by intramitochondrial ATP/ADP ratios

7 January 2021

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Cell respiration is controlled by ATP, an allosteric inhibitor of cytochrome-c oxidase

7 January 2021

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3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.

7 January 2021

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Palmitate decreases proton pumping of liver-type cytochrome c oxidase

7 January 2021

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ATP and ADP bind to cytochrome c oxidase and regulate its activity

7 January 2021

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Extramitochondrial ATP/ADP-ratios regulate cytochrome c oxidase activity via binding to the cytosolic domain of subunit IV

7 January 2021

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A second mechanism of respiratory control

7 January 2021

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The intramitochondrial ATP/ADP-ratio controls cytochrome c oxidase activity allosterically

7 January 2021

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New control of mitochondrial membrane potential and ROS formation--a hypothesis

7 January 2021

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7 January 2021

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7 January 2021

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Thyroid hormone action on mitochondrial energy transfer

7 January 2021

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Induction of UCP2 mRNA by thyroid hormones in rat heart

7 January 2021

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7 January 2021

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Dehydrogenase activation by Ca2+ in cells and tissues

7 January 2021

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7 January 2021

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7 January 2021

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Evidence of undiscovered cell regulatory mechanisms: phosphoproteins and protein kinases in mitochondria.

7 January 2021

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7 January 2021

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7 January 2021

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The allosteric ATP-inhibition of cytochrome c oxidase activity is reversibly switched on by cAMP-dependent phosphorylation

7 January 2021

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The current-voltage relationships of liposomes and mitochondria.

7 January 2021

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The rate of ATP-synthesis as a function of delta pH and delta psi catalyzed by the active, reduced H(+)-ATPase from chloroplasts

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism

7 January 2021

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The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis

7 January 2021

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Altered relationship between protonmotive force and respiration rate in non-phosphorylating liver mitochondria isolated from rats of different thyroid hormone status

7 January 2021

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Proton slippage in cytochrome c oxidase of Paracoccus denitrificans. Membrane-potential measurements with the two-subunit and three-subunit enzyme

7 January 2021

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Assessment of membrane potentials of mitochondrial populations in living cells

7 January 2021

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Electron spin resonance studies of intact mammalian skeletal muscle

7 January 2021

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Generating, partitioning, targeting and functioning of superoxide in mitochondria

7 January 2021

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Cooperation of a "reactive oxygen cycle" with the Q cycle and the proton cycle in the respiratory chain--superoxide generating and cycling mechanisms in mitochondria

7 January 2021

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High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

7 January 2021

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Mitochondria hyperpolarization is an early event in oxidized low-density lipoprotein-induced apoptosis in Caco-2 intestinal cells

7 January 2021

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Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress

7 January 2021

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Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus

7 January 2021

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Role of mitochondria in oxidative stress and aging

7 January 2021

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Cell transformation by the superoxide-generating oxidase Mox1

7 January 2021

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Reactive oxygen and DNA damage in mitochondria

7 January 2021

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Oxidants, antioxidants, and the degenerative diseases of aging

7 January 2021

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Role of reactive oxygen species (ROS) in apoptosis induction

7 January 2021

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Signalling apoptosis: a radical approach.

7 January 2021

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Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

7 January 2021

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Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

7 January 2021

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Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

7 January 2021

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In vitro ischemia promotes glutamate-mediated free radical generation and intracellular calcium accumulation in hippocampal pyramidal neurons

7 January 2021

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Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells.

7 January 2021

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NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria

7 January 2021

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Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells

7 January 2021

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Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture

7 January 2021

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A possible role of slips in cytochrome C oxidase in the antioxygen defense system of the cell.

7 January 2021

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Superoxide activates mitochondrial uncoupling proteins

7 January 2021

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Mechanism of action of reagents that uncouple oxidative phosphorylation

7 January 2021

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Biological applications of ionophores

7 January 2021

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Decoupling of oxidative phosphorylation and photophosphorylation

7 January 2021

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The mechanisms of fatty acid-induced proton permeability of the inner mitochondrial membrane.

7 January 2021

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Uncoupling: new approaches to an old problem of bioenergetics

7 January 2021

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pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids

7 January 2021

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Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation

7 January 2021

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Does the function of adenine nucleotide translocase in fatty acid uncoupling depend on the type of mitochondria?

7 January 2021

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Interaction of adenine nucleotides with the adenine nucleotide translocase regulates the developmental changes in proton conductance of the inner mitochondrial membrane.

7 January 2021

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ATP/ADP antiporter is involved in uncoupling of plant mitochondria induced by low concentrations of palmitate

7 January 2021

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Photomodification of mitochondrial proteins by azido fatty acids and its effect on mitochondrial energetics. Further evidence for the role of the ADP/ATP carrier in fatty-acid-mediated uncoupling

7 January 2021

1 reference

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Long-chain fatty acids act as protonophoric uncouplers of oxidative phosphorylation in rat liver mitochondria

7 January 2021

1 reference

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Cytoplasmic fatty acid-binding proteins: Their structure and genes

7 January 2021

1 reference

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Fatty acid-binding proteins in the heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2803%2900027-6

On the role of fatty acid binding proteins in fatty acid transport and metabolism

7 January 2021

1 reference

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Structure and function of the uncoupling protein from brown adipose tissue

7 January 2021

1 reference

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Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling.

7 January 2021

1 reference

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Quantification of fatty acid activation of the uncoupling protein in brown adipocytes and mitochondria from the guinea-pig

7 January 2021

1 reference

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Brown-adipose-tissue mitochondria: the regulation of the 32000-Mr uncoupling protein by fatty acids and purine nucleotides

7 January 2021

1 reference

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Coenzyme Q is an obligatory cofactor for uncoupling protein function

7 January 2021

1 reference

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The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter

7 January 2021

1 reference

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

7 January 2021

1 reference

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Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

7 January 2021

1 reference

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UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue

7 January 2021

1 reference

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UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells

7 January 2021

1 reference

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BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast

7 January 2021

1 reference

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Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis

7 January 2021

1 reference

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Adrenoceptors, uncoupling proteins, and energy expenditure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2803%2900027-6

Uncoupling proteins and thermoregulation

7 January 2021

1 reference

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No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2803%2900027-6

Calorigenic effect of diiodothyronines in the rat

7 January 2021

1 reference

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Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2803%2900027-6

Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2803%2900027-6

Influence of hyperthyroidism on superoxide radical and hydrogen peroxide production by rat liver submitochondrial particles

7 January 2021

1 reference

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Variable stoichiometry of proton pumping by the mitochondrial respiratory chain

7 January 2021

1 reference

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The stoichiometry of charge translocation by cytochrome oxidase and the cytochrome bc1 complex of mitochondria at high membrane potential

7 January 2021

1 reference

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Experimental discrimination between proton leak and redox slip during mitochondrial electron transport.

7 January 2021

1 reference

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The significance and mechanism of mitochondrial proton conductance

7 January 2021

1 reference

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Uncoupling to survive? The role of mitochondrial inefficiency in ageing

7 January 2021

1 reference

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Mitochondrial proton leak and the uncoupling proteins

7 January 2021

1 reference

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Mitochondrial proton leak and the uncoupling protein 1 homologues.

7 January 2021

1 reference

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Intrinsic metabolic depression in cells isolated from the hepatopancreas of estivating snails

7 January 2021

1 reference

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Inter-subunit rotation and elastic power transmission in F0F1-ATPase.

7 January 2021

1 reference

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ATP synthase: what dictates the size of a ring?

7 January 2021

1 reference

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The preferred stoichiometry of c subunits in the rotary motor sector of Escherichia coli ATP synthase is 10.

7 January 2021

1 reference

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Bacterial Na(+)-ATP synthase has an undecameric rotor

7 January 2021

1 reference

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Structural biology. Proton-powered turbine of a plant motor

7 January 2021

1 reference

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Bioenergetic properties of the thermoalkaliphilic Bacillus sp. strain TA2.A1.

7 January 2021

1 reference

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Pumping of protons from the mitochondrial matrix by cytochrome oxidase

7 January 2021

1 reference

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Oxygen activation and the conservation of energy in cell respiration

7 January 2021

1 reference

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Heme/Copper Terminal Oxidases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2803%2900027-6

The cytochrome chain of mitochondria exhibits variable H+/e- stoichiometry

7 January 2021

1 reference

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H+/e- stoichiometry of mitochondrial cytochrome complexes reconstituted in liposomes. Rate-dependent changes of the stoichiometry in the cytochrome c oxidase vesicles

7 January 2021

1 reference

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Factors affecting the H+/e- stoichiometry in mitochondrial cytochrome c oxidase: influence of the rate of electron flow and transmembrane delta pH

7 January 2021

1 reference

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Carboxyl residues in the iron-sulfur protein are involved in the proton pumping activity of P. denitrificans bc(1) complex.

7 January 2021

1 reference

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Cooperative coupling and role of heme a in the proton pump of heme-copper oxidases.

7 January 2021

1 reference

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X-ray structure and the reaction mechanism of bovine heart cytochrome c oxidase

7 January 2021

1 reference

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Cytochrome c oxidase: catalytic cycle and mechanisms of proton pumping--a discussion

7 January 2021

1 reference

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Mechanism of proton translocation by cytochrome c oxidase: a new four-stroke histidine cycle

7 January 2021

1 reference

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Where is 'outside' in cytochrome c oxidase and how and when do protons get there?

7 January 2021

1 reference

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On the role of subunit III in proton translocation in cytochrome c oxidase

7 January 2021

1 reference

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Slip and leak in mitochondrial oxidative phosphorylation

7 January 2021

1 reference

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Cytochrome c oxidase (heme aa3) from Paracoccus denitrificans: analysis of mutations in putative proton channels of subunit I.

7 January 2021

1 reference

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Mutations in the putative H-channel in the cytochrome c oxidase from Rhodobacter sphaeroides show that this channel is not important for proton conduction but reveal modulation of the properties of heme a

7 January 2021

1 reference

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Proton pumping by cytochrome oxidase: progress, problems and postulates

7 January 2021

1 reference

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Plasticity of proton pathways in haem-copper oxygen reductases.

7 January 2021

1 reference

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Tracing the D-pathway in reconstituted site-directed mutants of cytochrome c oxidase from Paracoccus denitrificans

7 January 2021

1 reference

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Relocation of an internal proton donor in cytochrome c oxidase results in an altered pK(a) and a non-integer pumping stoichiometry

7 January 2021

1 reference

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Fatty acids stimulate activity and restore respiratory control in a proton channel mutant of cytochrome c oxidase

7 January 2021

1 reference

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Membrane potential-controlled inhibition of cytochrome c oxidase by zinc

7 January 2021

1 reference

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Influence of structure, pH and membrane potential on proton movement in cytochrome oxidase.

7 January 2021

1 reference

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Nuclear genes for cytochrome c oxidase

7 January 2021

1 reference

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Mammalian subunit IV isoforms of cytochrome c oxidase

7 January 2021

1 reference

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Turkey cytochrome c oxidase contains subunit VIa of the liver type associated with low efficiency of energy transduction

7 January 2021

1 reference

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The possible role of isoforms of cytochrome c oxidase subunit VIa in mammalian thermogenesis.

7 January 2021

1 reference

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Tissue-specific regulation of bovine heart cytochrome-c oxidase activity by ADP via interaction with subunit VIa

7 January 2021

1 reference

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Tissue-specific regulation of cytochrome c oxidase efficiency by nucleotides

7 January 2021

1 reference

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Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2803%2900027-6

10.1016/S0005-2728(03)00027-6

7 January 2021

Identifiers

DOI

1 reference

6 August 2017

1 reference