(Q35102577)

6 August 2017

title

Macrophage polarization in pancreatic carcinoma: role of heparanase enzyme (English)

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6 August 2017

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4

Gabriel Nussbaum

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6 August 2017

Esther Hermano

1

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6 August 2017

Amichay Meirovitz

2

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6 August 2017

Karen Meir

3

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6 August 2017

Limor Appelbaum

5

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6 August 2017

Tamar Peretz

6

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6 August 2017

Michael Elkin

7

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6 August 2017

language of work or name

English

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publication date

18 October 2014

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Journal of the National Cancer Institute

6 August 2017

published in

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6 August 2017

volume

106

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6 August 2017

issue

12

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The stromal compartments in pancreatic cancer: are there any therapeutic targets?

6 August 2017

cites work

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Targeting the tumor microenvironment: from understanding pathways to effective clinical trials

9 July 2018

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Versatile role of heparanase in inflammation

9 July 2018

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Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

9 July 2018

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The heparanase/syndecan-1 axis in cancer: mechanisms and therapies

9 July 2018

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Neutralizing tumor-promoting chronic inflammation: a magic bullet?

9 July 2018

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Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines

9 July 2018

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Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses

9 July 2018

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MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells.

9 July 2018

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The pancreas cancer microenvironment

9 July 2018

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The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.

9 July 2018

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Downregulation of heparanase by RNA interference inhibits invasion and tumorigenesis of hepatocellular cancer cells in vitro and in vivo

9 July 2018

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TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated

9 July 2018

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Exogenous or endogenous Toll-like receptor ligands: which is the MVP in tumorigenesis?

9 July 2018

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Oncogenic transcription factors: cornerstones of inflammation-linked pancreatic carcinogenesis

9 July 2018

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Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

9 July 2018

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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

9 July 2018

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Macrophage infiltration predicts a poor prognosis for human ewing sarcoma

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer

9 July 2018

1 reference

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Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.

9 July 2018

1 reference

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Hallmarks of Cancer: The Next Generation

9 July 2018

1 reference

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Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

9 July 2018

1 reference

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Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting.

9 July 2018

1 reference

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Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Endogenous toll-like receptor ligands and their biological significance

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Macrophage diversity enhances tumor progression and metastasis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Mechanisms of tumor cell necrosis.

9 July 2018

1 reference

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Epidemiology of pancreatic cancer: an overview

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Cancer-related inflammation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected non-small cell lung cancer

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Downregulating the expression of heparanase inhibits the invasion, angiogenesis and metastasis of human hepatocellular carcinoma

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Conditional signaling by Toll-like receptor 4.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Inflammation and the development of pancreatic cancer

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Heparanase expression is a prognostic indicator for postoperative survival in pancreatic adenocarcinoma

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Heparanase expression in primary and metastatic pancreatic cancer

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Markers of mouse macrophage development detected by monoclonal antibodies

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Analysis of gene expression in the tumor-associated macrophage.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

Elevated serum heparanase-1 levels in patients with pancreatic carcinoma are associated with poor survival

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4334800

The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma

27 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326645

12 December 2020

Heparanase as mediator of angiogenesis: mode of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326645

12 December 2020

High heparanase activity in multiple myeloma is associated with elevated microvessel density

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326645

12 December 2020

Heparanase expression correlates with malignant potential in human colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326645

12 December 2020

Heparanase upregulation by colonic epithelium in inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326645

12 December 2020

Dynamics of the immune reaction to pancreatic cancer from inception to invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326645

12 December 2020

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25326645

12 December 2020

Identifiers

DOI

10.1093/JNCI/DJU332

1 reference

6 August 2017

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6 August 2017

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