(Q34632071)

3 August 2017

1 reference

title

Effector and memory T-cell differentiation: implications for vaccine development (English)

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3 August 2017

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1 reference

2

E John Wherry

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3 August 2017

Susan M Kaech

1

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3 August 2017

Raft Ahmed

series ordinal

3

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3 August 2017

publication date

1 April 2002

1 reference

Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

2

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3 August 2017

issue

4

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3 August 2017

page(s)

251-262

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Virus-specific CD8+ T-cell memory determined by clonal burst size

3 August 2017

cites work

1 reference

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Coordinate regulation of complex T cell populations responding to bacterial infection.

31 March 2020

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The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones

31 March 2020

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Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

31 March 2020

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Gene expression in antigen-specific CD8+ T cells during viral infection

31 March 2020

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Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection.

31 March 2020

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Response of naïve and memory CD8+ T cells to antigen stimulation in vivo

31 March 2020

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Activation changes the spectrum but not the diversity of genes expressed by T cells.

31 March 2020

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T cell receptor (TCR) engagement leads to activation-induced splicing of tumor necrosis factor (TNF) nuclear pre-mRNA

31 March 2020

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Cutting edge: OFF cycling of TNF production by antigen-specific CD8+ T cells is antigen independent

31 March 2020

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Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

31 March 2020

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Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

31 March 2020

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Lymphocyte traffic control by chemokines

31 March 2020

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Preferential localization of effector memory cells in nonlymphoid tissue

31 March 2020

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Visualizing the generation of memory CD4 T cells in the whole body

31 March 2020

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

31 March 2020

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Migratory properties of naive, effector, and memory CD8(+) T cells

31 March 2020

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Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

31 March 2020

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Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

31 March 2020

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Control of homeostasis of CD8+ memory T cells by opposing cytokines.

31 March 2020

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

31 March 2020

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Immunological memory and protective immunity: understanding their relation

31 March 2020

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Differential T cell costimulatory requirements in CD28-deficient mice

31 March 2020

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OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection

31 March 2020

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Novel mAbs reveal potent co-stimulatory activity of murine CD27.

31 March 2020

1 reference

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CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

31 March 2020

1 reference

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Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions

31 March 2020

1 reference

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CD28 affects the earliest signaling events generated by TCR engagement

31 March 2020

1 reference

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Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes

31 March 2020

1 reference

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Duration of TCR stimulation determines costimulatory requirement of T cells

31 March 2020

1 reference

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Role of CD40 Ligand and CD28 in Induction and Maintenance of Antiviral CD8+ Effector T Cell Responses

31 March 2020

1 reference

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Role of co-stimulation in CD8+ T cell activation.

31 March 2020

1 reference

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Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

31 March 2020

1 reference

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The duration of antigenic stimulation determines the fate of naive and effector T cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen-dependent and late cytokine-driven expansion and differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

A cellular calculus for signal integration by T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Early programming of T cell populations responding to bacterial infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Cutting edge: antigen-independent CD8 T cell proliferation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

IL-7 is critical for homeostatic proliferation and survival of naive T cells

31 March 2020

1 reference

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Cutting edge: naive T cells masquerading as memory cells

31 March 2020

1 reference

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Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses

31 March 2020

1 reference

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T lymphocyte dynamics during Listeria monocytogenes infection.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

T cells compete for access to antigen-bearing antigen-presenting cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Viral immune evasion due to persistence of activated T cells without effector function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

31 March 2020

1 reference

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Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection

31 March 2020

1 reference

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Priming of memory but not effector CD8 T cells by a killed bacterial vaccine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

The interplay between the duration of TCR and cytokine signaling determines T cell polarization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Migration and function of antigen-primed nonpolarized T lymphocytes in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Helper T cell differentiation is controlled by the cell cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4(+) T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Separable effector T cell populations specialized for B cell help or tissue inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Modelling T-cell memory by genetic marking of memory T cells in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Linear differentiation of cytotoxic effectors into memory T lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

CD4(+) T cell effectors can become memory cells with high efficiency and without further division.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Skewed maturation of memory HIV-specific CD8 T lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Cytokine-induced survival of activated T cells in vitro and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Type I interferons keep activated T cells alive

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

T-cell proliferation in vivo and the role of cytokines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Low-dose daily subcutaneous interleukin-2 in combination with highly active antiretroviral therapy in HIV+ patients: a randomized controlled trial.

31 March 2020

1 reference

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Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Antigen-specific cytotoxicity and cell number of adoptively transferred T cells are efficiently maintained in vivo by re-stimulation with an antigen/interleukin-2 fusion protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Differing roles of inflammation and antigen in T cell proliferation and memory generation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Costimulation in antiviral immunity: differential requirements for CD4(+) and CD8(+) T cell responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Homeostatic regulation of CD8+ T cells after antigen challenge in the absence of Fas (CD95)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1)

31 March 2020

1 reference

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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Homeostatic regulation of CD8+ T cells by perforin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Suicide induced by cytolytic activity controls the differentiation of memory CD8(+) T lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function

31 March 2020

1 reference

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Analysis of successful immune responses in persons infected with hepatitis C virus

31 March 2020

1 reference

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Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation

31 March 2020

1 reference

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Vaccine protection against functional CTL abnormalities in simian human immunodeficiency virus-infected rhesus monkeys.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection

31 March 2020

1 reference

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Protection against rotavirus infections by DNA vaccination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

A kinetic basis for T cell receptor repertoire selection during an immune response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

T cells down-modulate peptide-MHC complexes on APCs in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Massive expansion of antigen-specific CD8+ T cells during an acute virus infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

T cell affinity maturation by selective expansion during infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Strategies for designing and optimizing new generation vaccines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Establishment and persistence of virus-specific CD4+ and CD8+ T cell memory

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Molecular mechanisms of lymphocyte homing to peripheral lymph nodes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Measuring the diaspora for virus-specific CD8+ T cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Out of Eden: stem cells and their niches

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Telomerase activity in hematopoietic cells is associated with self-renewal potential

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Viral infections induce abundant numbers of senescent CD8 T cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Regulating T helper cell immunity through antigen responsiveness and calcium entry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

IL-7 administration alters the CD4:CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Mechanisms of cytokine synergy essential for vaccine protection against viral challenge

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

Effects of granulocyte-macrophage colony stimulating factor (GM-CSF) in vivo on cytokine production and proliferation by spleen cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI778

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI778

1 reference

Dimensions Publication ID

3 August 2017

1039181299

0 references

1 reference