(Q34619789)

3 August 2017

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title

Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity (English)

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3 August 2017

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1

F Nina Papavasiliou

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author name string

F Nina Papavasiliou

series ordinal

1

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3 August 2017

David G Schatz

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 April 2002

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3 August 2017

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3 August 2017

volume

109 Suppl

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3 August 2017

page(s)

S35-44

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Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

3 August 2017

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The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer

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Increased transcription levels induce higher mutation rates in a hypermutating cell line

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The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line

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Origin of Antibody Variation

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DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

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Ku80 is required for immunoglobulin isotype switching

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Evolution of somatic hypermutation and gene conversion in adaptive immunity

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Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch

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DNA sequences at immunoglobulin switch region recombination sites

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Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

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Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

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7 January 2021

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

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Somatic hypermutation in the heavy chain locus correlates with transcription

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Emerging links between hypermutation of antibody genes and DNA polymerases

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Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

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Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

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7 January 2021

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

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7 January 2021

Hypermutation: give us a break

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7 January 2021

AID is essential for immunoglobulin V gene conversion in a cultured B cell line

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Cell-cycle regulation of mammalian DNA double-strand-break repair

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7 January 2021

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

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Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction

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Towards an understanding of somatic hypermutation

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DNA double strand break repair in mammalian cells

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7 January 2021

Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain

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Biochemistry and genetics of eukaryotic mismatch repair

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7 January 2021

Cellular origin of human B-cell lymphomas.

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7 January 2021

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

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V(D)J recombination and the cell cycle.

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7 January 2021

Somatic hypermutation: how many mechanisms diversify V region sequences?

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7 January 2021

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

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7 January 2021

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

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7 January 2021

Mechanism and control of class-switch recombination

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7 January 2021

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

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7 January 2021

Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes

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7 January 2021

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

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7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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7 January 2021

Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice

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7 January 2021

The AID enzyme induces class switch recombination in fibroblasts

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7 January 2021

The Targeting of Somatic Hypermutation Closely Resembles That of Meiotic Mutation

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7 January 2021

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

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7 January 2021

Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae

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7 January 2021

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

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7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

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7 January 2021

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

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7 January 2021

Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination

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7 January 2021

The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially

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7 January 2021

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

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7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

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7 January 2021

Mismatch repair and immunoglobulin gene hypermutation: did we learn something?

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7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

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7 January 2021

The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

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7 January 2021

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

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Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

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7 January 2021

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions

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7 January 2021

Gene conversion and homologous recombination in murine B cells

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7 January 2021

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

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7 January 2021

The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression

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7 January 2021

Cell Selection by Antigen in the Immune Response

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7 January 2021

A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript

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7 January 2021

Cis-acting sequences that affect somatic hypermutation of Ig genes

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7 January 2021

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

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7 January 2021

Allergy and Immunology

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7 January 2021

Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro

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7 January 2021

Somatic generation of antibody diversity

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7 January 2021

The transcriptional promoter regulates hypermutation of the antibody heavy chain locus

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7 January 2021

Variability in the Lambda Light Chain Sequences of Mouse Antibody

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7 January 2021

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

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7 January 2021

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

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7 January 2021

Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism.

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7 January 2021

DNA repair: knockouts still mutating after first round

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7 January 2021

The Somatic Hypermutation Activity of a Follicular Lymphoma Links to Large Insertions and Deletions of Immunoglobulin Genes

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7 January 2021

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

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7 January 2021

10.1016/S0092-8674(02)00706-7

Identifiers

DOI

1 reference

3 August 2017

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