(Q34567458)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

review article

1 reference

title

Molecular bases of progeroid syndromes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Nicolas Levy

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

author name string

Pierre Cau

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

publication date

1 October 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

volume

15 Spec No 2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

page(s)

R151-61

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?

30 December 2019

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The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

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The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta

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21 January 2018

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Functional and physical interaction between WRN helicase and human replication protein A

21 January 2018

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The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

21 January 2018

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Functional interaction between the Werner Syndrome protein and DNA polymerase delta

21 January 2018

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Physical and functional interaction between p53 and the Werner's syndrome protein

21 January 2018

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TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

21 January 2018

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Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

21 January 2018

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The spectrum of WRN mutations in Werner syndrome patients

21 January 2018

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Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

21 January 2018

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p53-mediated apoptosis is attenuated in Werner syndrome cells

21 January 2018

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Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

21 January 2018

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Mechanisms of DNA damage recognition and strand discrimination in human nucleotide excision repair

21 January 2018

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Damage recognition in nucleotide excision repair of DNA.

21 January 2018

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The comings and goings of nucleotide excision repair factors on damaged DNA

21 January 2018

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Molecular mechanisms of mammalian global genome nucleotide excision repair.

21 January 2018

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Cancer in xeroderma pigmentosum and related disorders of DNA repair

21 January 2018

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The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

21 January 2018

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Molecular analysis of mutations in the CSB (ERCC6) gene in patients with Cockayne syndrome

21 January 2018

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UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells

21 January 2018

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Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro

21 January 2018

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Cockayne syndrome: Review of 140 cases

21 January 2018

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Retracted: A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: implications for a second XPG function

21 January 2018

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The protein shuffle. Sequential interactions among components of the human nucleotide excision repair pathway

21 January 2018

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21 January 2018

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21 January 2018

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Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis

21 January 2018

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Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C

21 January 2018

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Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation

21 January 2018

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21 January 2018

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21 January 2018

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Restrictive dermopathy: a case report and a critical review of all hypotheses of its origin

21 January 2018

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Restrictive dermopathy: report of a case and review of the literature

21 January 2018

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Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype

21 January 2018

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Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

21 January 2018

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Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A role for p53 in maintaining and establishing the quiescence growth arrest in human cells

21 January 2018

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21 January 2018

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21 January 2018

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A mitotic lamin B matrix induced by RanGTP required for spindle assembly

21 January 2018

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The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro

21 January 2018

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Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation

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21 January 2018

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21 January 2018

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Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

21 January 2018

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Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

21 January 2018

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A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

21 January 2018

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Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

21 January 2018

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Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

21 January 2018

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Lipid posttranslational modifications. Farnesyl transferase inhibitors

21 January 2018

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Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.

21 January 2018

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Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina

21 January 2018

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Molecular clues into the pathogenesis of statin-mediated muscle toxicity

21 January 2018

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Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

21 January 2018

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From immature lamin to premature aging: molecular pathways and therapeutic opportunities.

21 January 2018

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Murine models of life span extension

21 January 2018

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The plasticity of aging: insights from long-lived mutants

21 January 2018

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Understanding aging: revealing order out of chaos

21 January 2018

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

21 January 2018

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Mitochondria, oxidants, and aging

21 January 2018

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Reactive oxygen intermediates in biochemistry

21 January 2018

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Normal oxidative damage to mitochondrial and nuclear DNA is extensive

21 January 2018

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The mitochondrial DNA polymerase as a target of oxidative damage

21 January 2018

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

21 January 2018

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Decline in skeletal muscle mitochondrial function with aging in humans

21 January 2018

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Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

21 January 2018

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

21 January 2018

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Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

21 January 2018

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Extension of murine life span by overexpression of catalase targeted to mitochondria

21 January 2018

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Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein

21 January 2018

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Mitochondrial protein p32 can accumulate in the nucleus.

21 January 2018

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Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro

21 January 2018

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The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation

21 January 2018

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Temporal association of protamine 1 with the inner nuclear membrane protein lamin B receptor during spermiogenesis

21 January 2018

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Systematic identification of human mitochondrial disease genes through integrative genomics

21 January 2018

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Mechanisms of protein import into mitochondria

21 January 2018

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p53 mutant mice that display early ageing-associated phenotypes

21 January 2018

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Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.

21 January 2018

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Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma

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p53 regulates mitochondrial respiration

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The antioxidant function of the p53 tumor suppressor

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Calorie restriction, SIRT1 and metabolism: understanding longevity

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The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension

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Sirtuins: Sir2-related NAD-dependent protein deacetylases

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Calorie restriction--the SIR2 connection

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Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

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Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

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Role of sirtuin proteins in life extension by caloric restriction

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IGF-1 signaling and aging.

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https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

Suppression of aging in mice by the hormone Klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

Ticking fast or ticking slow, through Shc must you go?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL214

21 January 2018

Identifiers

DOI

10.1093/HMG/DDL214

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16987878%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference