(Q34434226)

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Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

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Europe PubMed Central

PubMed publication ID

2 August 2017

Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1. (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

phosphorylation

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Fixman ED

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Holgado-Madruga M

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Nguyen L

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Kamikura DM

4

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Fournier TM

5

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Wong AJ

6

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Park M

7

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

language of work or name

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publication date

1 August 1997

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Europe PubMed Central

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2 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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2 August 2017

272

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Europe PubMed Central

PubMed publication ID

2 August 2017

32

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Europe PubMed Central

PubMed publication ID

2 August 2017

20167-20172

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1 reference

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Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development

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Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure

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Purification and subunit structure of hepatocyte growth factor from rat platelets

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Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells

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Scatter factor/hepatocyte growth factor is essential for liver development

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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

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Molecular cloning of a new transforming gene from a chemically transformed human cell line.

1 reference

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21 January 2018

Mechanism of met oncogene activation

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Oncogenic activation of tyrosine kinases

1 reference

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Identification of tyrosine 489 in the carboxy terminus of the Tpr-Met oncoprotein as a major site of autophosphorylation

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Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase

1 reference

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Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

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Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

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Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor

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SH2 domains recognize specific phosphopeptide sequences

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

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Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

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Coupling of the Proto-oncogene Product c-Cbl to the Epidermal Growth Factor Receptor

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The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

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Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

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Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors

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v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

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Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1 reference

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

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Identifiers

10.1074/JBC.272.32.20167

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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