(Q34376186)

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12 March 2020

title

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice (English)

1 reference

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12 March 2020

1 reference

3

1 reference

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12 March 2020

Matthew J. Wood

5

1 reference

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12 March 2020

Paul Simons

8

1 reference

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12 March 2020

Lydia Alvarez-Erviti

10

1 reference

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12 March 2020

7

Anthony H V Schapira

1 reference

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12 March 2020

1

J Mark Cooper

1 reference

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12 March 2020

author name string

P B Oscar Wiklander

2

1 reference

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12 March 2020

Raya Al-Shawi

4

1 reference

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12 March 2020

Mansi Vithlani

6

1 reference

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12 March 2020

Samir El-Andaloussi

9

1 reference

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12 March 2020

language of work or name

English

0 references

publication date

11 August 2014

1 reference

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12 March 2020

1 reference

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12 March 2020

volume

29

1 reference

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12 March 2020

issue

12

1 reference

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12 March 2020

page(s)

1476-1485

1 reference

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Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease.

12 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Parkinson's disease: gene therapies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Genetic animal models of Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Near complete rescue of experimental Parkinson's disease with intravenous, non-viral GDNF gene therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

In vivo silencing of alpha-synuclein using naked siRNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

alpha-Synuclein locus triplication causes Parkinson's disease

6 July 2018

1 reference

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Staging of brain pathology related to sporadic Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

alpha-Synuclein is phosphorylated in synucleinopathy lesions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

Drug delivery to the nervous system

6 July 2018

1 reference

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

6 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FMDS.25978

Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMDS.25978

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMDS.25978

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMDS.25978

Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMDS.25978

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4204174

27 October 2018

Identifiers

DOI

10.1002/MDS.25978

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25112864%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

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12 March 2020

PubMed publication ID

25112864

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25112864%20AND%20SRC:MED&resulttype=core&format=json