(Q34325371)

1 August 2017

1 reference

title

Failure of the ubiquitin-proteasome system in Parkinson's disease (English)

1 reference

ubiquitin-proteasome system

1 August 2017

main subject

0 references

1 reference

Isacson O

4

1 reference

ORCID Public Data File 2021

author name string

McNaught KS

1

1 reference

1 August 2017

Olanow CW

2

1 reference

1 August 2017

Halliwell B

3

1 reference

1 August 2017

Jenner P

5

1 reference

1 August 2017

language of work or name

English

0 references

publication date

1 August 2001

1 reference

Nature Reviews Neuroscience

1 August 2017

published in

1 reference

1 August 2017

volume

2

1 reference

1 August 2017

issue

8

1 reference

1 August 2017

page(s)

589-594

1 reference

Alpha-synuclein and neurodegenerative diseases

1 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Impaired clearance of oxidised proteins in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

The proteasome, a novel protease regulated by multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

A large kindred with autosomal dominant Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Protein nitration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Aggresomes: a cellular response to misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Dynamic association of proteasomal machinery with the centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Aggresomes, inclusion bodies and protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Degradation of oxidized proteins by the 20S proteasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

The ubiquitin pathway in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Clinical and neuropathological aspects of autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Caretaker or undertaker? The role of the proteasome in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

Neuropathology of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Pathology and Biology of the Lewy Body

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Clinical and pathological features of a parkinsonian syndrome in a family with an Ala53Thr ?-synuclein mutation

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

The genetics of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Structure/function in neuroprotection and apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Degradation of alpha-synuclein by proteasome

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Understanding cell death in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2F35086067

7 January 2021

Identifiers

DOI

10.1038/35086067

1 reference

Dimensions Publication ID

1 August 2017

1001776700

0 references

1 reference