(Q34300569)

1 August 2017

title

p53 post-translational modification: deregulated in tumorigenesis (English)

1 reference

post-translational protein modification

1 August 2017

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932800

29 July 2024

author name string

Chao Dai

series ordinal

1

1 reference

1 August 2017

Wei Gu

series ordinal

2

1 reference

1 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20932800

29 July 2024

publication date

1 November 2010

1 reference

full work available at URL

1 August 2017

https://europepmc.org/articles/pmc2978905?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932800

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20932800/pdf/?tool=EBI

29 July 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932800

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20932800/?tool=EBI

29 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932800

https://europepmc.org/articles/PMC2978905

29 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932800

https://europepmc.org/articles/PMC2978905?pdf=render

29 July 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932800

https://doi.org/10.1016/j.molmed.2010.09.002

29 July 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20932800

https://api.elsevier.com/content/article/PII:S1471491410001309?httpAccept=text/xml

29 July 2024

1 reference

10.1016/J.MOLMED.2010.09.002

Crossref

DOI

https://api.crossref.org/works/10.1016/J.MOLMED.2010.09.002

https://api.elsevier.com/content/article/PII:S1471491410001309?httpAccept=text/plain

29 July 2024

1 reference

10.1016/J.MOLMED.2010.09.002

Crossref

DOI

https://api.crossref.org/works/10.1016/J.MOLMED.2010.09.002

Trends in Molecular Medicine

29 July 2024

published in

1 reference

1 August 2017

volume

16

1 reference

1 August 2017

issue

11

1 reference

1 August 2017

page(s)

528-536

1 reference

G9a and Glp methylate lysine 373 in the tumor suppressor p53

1 August 2017

cites work

1 reference

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USP10 regulates p53 localization and stability by deubiquitinating p53

6 July 2018

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Inactivation of HAUSP in vivo modulates p53 function

6 July 2018

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GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress

6 July 2018

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CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.

6 July 2018

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Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

6 July 2018

1 reference

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The multiple levels of regulation by p53 ubiquitination

6 July 2018

1 reference

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Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53.

6 July 2018

1 reference

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6 July 2018

Modes of p53 regulation

1 reference

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Cytoplasmic functions of the tumour suppressor p53.

6 July 2018

1 reference

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Regulation of p53 family members by the ubiquitin-like SUMO system

6 July 2018

1 reference

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SIRT1, is it a tumor promoter or tumor suppressor?

6 July 2018

1 reference

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MSL2 promotes Mdm2-independent cytoplasmic localization of p53

6 July 2018

1 reference

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Arginine methylation regulates the p53 response

6 July 2018

1 reference

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Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series

6 July 2018

1 reference

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Is there a code embedded in proteins that is based on post-translational modifications?

6 July 2018

1 reference

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miR-34a repression of SIRT1 regulates apoptosis

6 July 2018

1 reference

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p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts

6 July 2018

1 reference

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A dual role of p53 in the control of autophagy

6 July 2018

1 reference

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Protein methylation: a new mechanism of p53 tumor suppressor regulation

6 July 2018

1 reference

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A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

6 July 2018

1 reference

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Acetylation is indispensable for p53 activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Regulation of autophagy by cytoplasmic p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

6 July 2018

1 reference

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Negative regulation of the deacetylase SIRT1 by DBC1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

DBC1 is a negative regulator of SIRT1

6 July 2018

1 reference

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The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

New nomenclature for chromatin-modifying enzymes

6 July 2018

1 reference

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Concepts in sumoylation: a decade on

6 July 2018

1 reference

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Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

6 July 2018

1 reference

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The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

p53 is regulated by the lysine demethylase LSD1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Modulation of p53 function by SET8-mediated methylation at lysine 382

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

SIRT1 is significantly elevated in mouse and human prostate cancer.

6 July 2018

1 reference

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The role of ubiquitination in the direct mitochondrial death program of p53.

6 July 2018

1 reference

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How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

p53 in health and disease

6 July 2018

1 reference

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DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

The amplified WWP1 gene is a potential molecular target in breast cancer

6 July 2018

1 reference

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Coping with stress: multiple ways to activate p53.

6 July 2018

1 reference

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MDMX: from bench to bedside

6 July 2018

1 reference

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A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

6 July 2018

1 reference

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Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

6 July 2018

1 reference

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Strong expression of a longevity-related protein, SIRT1, in Bowen's disease

6 July 2018

1 reference

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Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

6 July 2018

1 reference

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Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'

6 July 2018

1 reference

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

6 July 2018

1 reference

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CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation

6 July 2018

1 reference

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Repression of p53 activity by Smyd2-mediated methylation

6 July 2018

1 reference

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FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity

6 July 2018

1 reference

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Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer

6 July 2018

1 reference

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Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways

6 July 2018

1 reference

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Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage

6 July 2018

1 reference

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Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1

6 July 2018

1 reference

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Divorcing ARF and p53: an unsettled case

6 July 2018

1 reference

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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

6 July 2018

1 reference

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Posttranslational phosphorylation of mutant p53 protein in tumor development

6 July 2018

1 reference

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The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression

6 July 2018

1 reference

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Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice

6 July 2018

1 reference

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p53 ubiquitination: Mdm2 and beyond

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

A genomic and functional inventory of deubiquitinating enzymes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

The coordinate regulation of the p53 and mTOR pathways in cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Regulation of p53 activity through lysine methylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Post-translational modification of p53 in tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

A dynamic role of HAUSP in the p53-Mdm2 pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Inhibition of p53 degradation by Mdm2 acetylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Negative control of p53 by Sir2alpha promotes cell survival under stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Deacetylation of p53 modulates its effect on cell growth and apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Expression of p53 protein phosphorylated at serine 20 and serine 392 in malignant and benign ovarian neoplasms: correlation with clinicopathological parameters of tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

SnapShot: p53 posttranslational modifications

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978905

The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20932800

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20932800

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLMED.2010.09.002

1 reference

1 August 2017

1 reference

1 August 2017

1 reference