(Q34149479)

31 July 2017

title

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription (English)

1 reference

31 July 2017

Hiroyuki Takai

1

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31 July 2017

Kazuhito Naka

2

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31 July 2017

Yuki Okada

3

1 reference

31 July 2017

Miho Watanabe

4

1 reference

31 July 2017

Naoki Harada

5

1 reference

31 July 2017

Shin'ichi Saito

6

1 reference

31 July 2017

Carl W Anderson

7

1 reference

31 July 2017

Ettore Appella

8

1 reference

31 July 2017

Makoto Nakanishi

9

1 reference

31 July 2017

Hiroshi Suzuki

10

1 reference

31 July 2017

Kazuo Nagashima

11

1 reference

31 July 2017

Hirofumi Sawa

12

1 reference

31 July 2017

Kyoji Ikeda

13

1 reference

31 July 2017

Noboru Motoyama

14

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31 July 2017

language of work or name

English

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publication date

1 October 2002

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31 July 2017

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31 July 2017

volume

21

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31 July 2017

issue

19

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31 July 2017

page(s)

5195-5205

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Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

31 July 2017

cites work

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Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome

5 July 2018

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Mutation of mouse p53 Ser23 and the response to DNA damage

5 July 2018

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

5 July 2018

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Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

5 July 2018

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CHK2 kinase--a busy messenger.

5 July 2018

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

5 July 2018

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Negative control of p53 by Sir2alpha promotes cell survival under stress

5 July 2018

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Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

5 July 2018

1 reference

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Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status.

5 July 2018

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Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

5 July 2018

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Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3

5 July 2018

1 reference

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Regulation of p53 localization

5 July 2018

1 reference

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Post-translational modifications and activation of p53 by genotoxic stresses

5 July 2018

1 reference

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

5 July 2018

1 reference

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

The many substrates and functions of ATM

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

5 July 2018

1 reference

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Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Rapid destruction of human Cdc25A in response to DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

5 July 2018

1 reference

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

ATM: a mediator of multiple responses to genotoxic stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

5 July 2018

1 reference

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Regulation of p53 function and stability by phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

The complexity of p53 modulation: emerging patterns from divergent signals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

DNA damage activates p53 through a phosphorylation-acetylation cascade

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Enhanced phosphorylation of p53 by ATM in response to DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

BRCA1 required for transcription-coupled repair of oxidative DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Atm-deficient mice: a paradigm of ataxia telangiectasia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

p53 is required for radiation-induced apoptosis in mouse thymocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Radiation-induced cell cycle arrest compromised by p21 deficiency

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Thymocyte apoptosis induced by p53-dependent and independent pathways.

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDF506

Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDF506

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=129029

Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer

28 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/12356735

12 December 2020

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12356735

12 December 2020

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://pubmed.ncbi.nlm.nih.gov/12356735

12 December 2020

Loss of atm radiosensitizes multiple p53 null tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/12356735

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/CDF506

1 reference

31 July 2017

1 reference

31 July 2017

1 reference