(Q34038652)

30 July 2017

title

Chromatin proteins and modifications as drug targets (English)

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30 July 2017

1

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30 July 2017

Dashyant Dhanak

2

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30 July 2017

language of work or name

English

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publication date

1 October 2013

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30 July 2017

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30 July 2017

volume

502

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30 July 2017

issue

7472

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30 July 2017

page(s)

480-488

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The complex language of chromatin regulation during transcription

30 July 2017

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p53 is regulated by the lysine demethylase LSD1

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Minireview: role of protein methylation and demethylation in nuclear hormone signaling.

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Histone modifying enzymes and cancer: going beyond histones.

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Novel mutations target distinct subgroups of medulloblastoma.

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The role of mutations in epigenetic regulators in myeloid malignancies

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Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

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New insights to the MLL recombinome of acute leukemias

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hDOT1L links histone methylation to leukemogenesis

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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

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Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

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The polycomb group protein EZH2 is involved in progression of prostate cancer

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Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

21 January 2018

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

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Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma

21 January 2018

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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

21 January 2018

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

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Analysis of the coding genome of diffuse large B-cell lymphoma

21 January 2018

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EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas

21 January 2018

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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

21 January 2018

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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

21 January 2018

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Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells

21 January 2018

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

21 January 2018

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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

21 January 2018

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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

21 January 2018

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Molecular mechanisms and potential functions of histone demethylases

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Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

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Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components

21 January 2018

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A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

21 January 2018

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Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

21 January 2018

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KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

21 January 2018

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Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation

21 January 2018

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Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

21 January 2018

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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

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LSD1 inhibition: a therapeutic strategy in cancer?

21 January 2018

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Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

21 January 2018

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Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.

21 January 2018

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Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

21 January 2018

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Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

21 January 2018

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The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 January 2018

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Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

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Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells

21 January 2018

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Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

21 January 2018

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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

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Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency

21 January 2018

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Histone recognition and large-scale structural analysis of the human bromodomain family

21 January 2018

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The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis

21 January 2018

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Suppression of inflammation by a synthetic histone mimic

21 January 2018

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Selective inhibition of BET bromodomains

21 January 2018

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Demystified molecular pathology of NUT midline carcinomas

21 January 2018

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

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Targeting MYCN in neuroblastoma by BET bromodomain inhibition

21 January 2018

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EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

21 January 2018

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

21 January 2018

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

21 January 2018

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A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

21 January 2018

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

21 January 2018

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Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

21 January 2018

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HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

21 January 2018

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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

21 January 2018

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Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition

21 January 2018

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An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1

21 January 2018

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Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

21 January 2018

1 reference

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Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines

21 January 2018

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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

21 January 2018

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A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma

21 January 2018

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Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors

21 January 2018

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Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies.

21 January 2018

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

21 January 2018

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N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1).

21 January 2018

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Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)

21 January 2018

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PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

21 January 2018

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Small-Molecule Ligands of Methyl-Lysine Binding Proteins

21 January 2018

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Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

21 January 2018

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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

21 January 2018

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Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

21 January 2018

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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

21 January 2018

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12 December 2020

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

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12 December 2020

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

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12 December 2020

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines

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12 December 2020

Molecular biology. Genetic events that shape the cancer epigenome

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12 December 2020

Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker

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12 December 2020

Molecular mechanisms and potential functions of histone demethylases

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7 January 2021

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Identifiers

DOI

10.1038/NATURE12751

1 reference

release_yv6xod424nhhtdpwuwgvkkoiwq

30 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/yv6xod424nhhtdpwuwgvkkoiwq

24 November 2022

mapped directly with Wikidata item

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