(Q34032136)

30 July 2017

title

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication (English)

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30 July 2017

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5

Christian Toso

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30 July 2017

Kathrin Maedler

1

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author name string

Adriano Fontana

2

1 reference

30 July 2017

Frédéric Ris

3

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30 July 2017

Pavel Sergeev

4

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30 July 2017

José Oberholzer

6

1 reference

30 July 2017

Roger Lehmann

7

1 reference

30 July 2017

Felix Bachmann

8

1 reference

30 July 2017

Andrea Tasinato

9

1 reference

30 July 2017

Giatgen A Spinas

10

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30 July 2017

Philippe A Halban

11

1 reference

30 July 2017

Marc Y Donath

12

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30 July 2017

language of work or name

English

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publication date

1 June 2002

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

99

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30 July 2017

issue

12

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30 July 2017

page(s)

8236-8241

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High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

30 July 2017

cites work

1 reference

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Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

5 July 2018

1 reference

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Insulin resistance is not necessarily an essential component of type 2 diabetes

5 July 2018

1 reference

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

5 July 2018

1 reference

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Islet growth and development in the adult

5 July 2018

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Human islet transplantation: lessons from 13 autologous and 13 allogeneic transplantations

5 July 2018

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Differential regulation and function of Fas expression on glial cells

5 July 2018

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Expression of cellular FLICE-inhibitory protein in human coronary arteries and in a rat vascular injury model

5 July 2018

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Neogenesis vs. apoptosis As main components of pancreatic beta cell ass changes in glucose-infused normal and mildly diabetic adult rats

5 July 2018

1 reference

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Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

5 July 2018

1 reference

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Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance

5 July 2018

1 reference

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Inhibition of death receptor signals by cellular FLIP

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Proliferation and differentiation in the human fetal endocrine pancreas

5 July 2018

1 reference

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Mouse islet cell lysis mediated by interleukin-1-induced Fas.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance

5 July 2018

1 reference

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Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM?

5 July 2018

1 reference

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Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible?

5 July 2018

1 reference

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Growth Factor/Matrix-Induced Proliferation of Human Adult β-Cells

5 July 2018

1 reference

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Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Automated method for isolation of human pancreatic islets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123051

Improved human islet isolation using a new enzyme blend, liberase

29 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Culture of adult human islet preparations with hepatocyte growth factor and 804G matrix is mitogenic for duct cells but not for beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Poor capacity for proliferation of pancreatic beta-cells in Otsuka-Long-Evans-Tokushima Fatty rat: a model of spontaneous NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Inhibition of fas death signals by FLIPs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Sorting human beta-cells consequent to targeted expression of green fluorescent protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Early development of beta-cells is impaired in the GK rat model of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Ultraviolet light downregulates CD95 ligand and TRAIL receptor expression facilitating actinic keratosis and squamous cell carcinoma formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12060768

12 December 2020

Identifiers

DOI

10.1073/PNAS.122686299

1 reference

30 July 2017

0 references

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30 July 2017

1 reference