(Q34016504)

30 July 2017

title

Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity (English)

1 reference

evasion of host immune response

30 July 2017

main subject

1 reference

Jehan J El-Jawhari

2

0 references

Graham P. Cook

object named as

Graham P Cook

7

0 references

author name string

Erica B Wilson

1

1 reference

30 July 2017

Abbie L Neilson

3

1 reference

30 July 2017

Geoffrey D Hall

4

1 reference

30 July 2017

Alan A Melcher

5

1 reference

30 July 2017

Josephine L Meade

6

1 reference

30 July 2017

language of work or name

English

0 references

publication date

6 September 2011

1 reference

30 July 2017

1 reference

30 July 2017

volume

6

1 reference

30 July 2017

issue

9

1 reference

30 July 2017

page(s)

e22842

1 reference

Creative Commons Attribution 4.0 International

30 July 2017

copyright license

start time

6 September 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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5 July 2018

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A human NK cell activation/inhibition threshold allows small changes in the target cell surface phenotype to dramatically alter susceptibility to NK cells.

5 July 2018

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The polarization of immune cells in the tumour environment by TGFbeta

5 July 2018

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TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression

5 July 2018

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5 July 2018

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TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

5 July 2018

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5 July 2018

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Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells

5 July 2018

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Oncogenic stress sensed by the immune system: role of natural killer cell receptors

5 July 2018

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Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells

5 July 2018

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Non-Smad pathways in TGF-beta signaling

5 July 2018

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Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1.

5 July 2018

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Accelerated tumor growth in mice deficient in DNAM-1 receptor

5 July 2018

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5 July 2018

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The tumor microenvironment and its role in promoting tumor growth

5 July 2018

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Positive and negative influences of regulatory T cells on tumour immunity.

5 July 2018

1 reference

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TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells

5 July 2018

1 reference

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Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D.

5 July 2018

1 reference

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NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy

5 July 2018

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Modulation of natural killer cells by human cytomegalovirus

5 July 2018

1 reference

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TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

5 July 2018

1 reference

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Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer

5 July 2018

1 reference

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Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

Mechanisms of immune evasion by tumors

5 July 2018

1 reference

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TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

NK cells infiltrating a MHC class I-deficient lung adenocarcinoma display impaired cytotoxic activity toward autologous tumor cells associated with altered NK cell-triggering receptors

5 July 2018

1 reference

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Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo.

5 July 2018

1 reference

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Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.

5 July 2018

1 reference

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In vivo survival and homeostatic proliferation of natural killer cells.

5 July 2018

1 reference

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Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

An activating immunoreceptor complex formed by NKG2D and DAP10

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

Decreased tumor surveillance in perforin-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

TGF beta down-regulates TLiSA1 expression and inhibits the differentiation of precursor lymphocytes into CTL and LAK cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3167809

Deficient expression of NCR in NK cells from acute myeloid leukemia: Evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022842

Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022842

Enhanced in vivo growth of lymphoma tumors in the absence of the NK-activating receptor NKp46/NCR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022842

Activin-A attenuates several human natural killer cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022842

Farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer: a phase I study

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022842

Proteolytic activation of the cytotoxic phenotype during human NK cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022842

DNAX Accessory Molecule-1 Mediated Recognition of Freshly Isolated Ovarian Carcinoma by Resting Natural Killer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022842

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21909397

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21909397

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21909397

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0022842

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference