(Q33974618)

30 July 2017

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title

The growing impact of click chemistry on drug discovery (English)

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30 July 2017

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2

K Barry Sharpless

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30 July 2017

1

Hartmuth C Kolb

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30 July 2017

publication date

1 December 2003

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30 July 2017

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30 July 2017

volume

8

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30 July 2017

issue

24

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30 July 2017

page(s)

1128-1137

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The properties of known drugs. 1. Molecular frameworks

30 July 2017

cites work

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7 January 2021

The art and practice of structure-based drug design: A molecular modeling perspective

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7 January 2021

Natural products as sources of new drugs over the period 1981-2002.

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7 January 2021

Recent natural products based drug development: a pharmaceutical industry perspective

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7 January 2021

Catalytic Asymmetric Hetero-Diels-Alder Reactions of Carbonyl Compounds and Imines

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7 January 2021

Catalytic Asymmetric Dihydroxylation

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7 January 2021

Tert-butylsulfonamide. A new nitrogen source for catalytic aminohydroxylation and aziridination of olefins

1 reference

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7 January 2021

A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry

1 reference

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7 January 2021

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

1 reference

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7 January 2021

Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Click linker: efficient and high-yielding synthesis of a new family of SPOS resins by 1,3-dipolar cycloaddition

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7 January 2021

Solid-phase synthesis of 1,2,3-triazoles via 1,3-dipolar cycloaddition

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7 January 2021

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

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7 January 2021

Multivalent Neoglycoconjugates by Regiospecific Cycloaddition of Alkynes and Azides Using Organic-Soluble Copper Catalysts

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7 January 2021

Enzyme action in glycoprotein synthesis

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7 January 2021

Carbohydrate mimetics-based glycosyltransferase inhibitors

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7 January 2021

Synthesis and evaluation of transition-state analogue inhibitors of alpha-1,3-fucosyltransferase

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7 January 2021

HIV protease inhibitors: peptidomimetic drugs and future perspectives

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7 January 2021

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

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7 January 2021

Self-assembling cytotoxins

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7 January 2021

Synergism through direct covalent bonding between agents: a strategy for rational design of chemotherapeutic combinations

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7 January 2021

Using an Enzyme's Active Site To Template Inhibitors This work was supported by the Centre National de la Recherche Scientifique and by the Ecole Polytechnique (predoctoral fellowship to R.N.). We thank Prof. Jean-Marie Lehn for stimulating discussi

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Dynamic combinatorial chemistry

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7 January 2021

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1 reference

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7 January 2021

Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

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7 January 2021

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

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7 January 2021

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

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7 January 2021

Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis

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7 January 2021

A chemical approach for identifying O-GlcNAc-modified proteins in cells

1 reference

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7 January 2021

Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Cell surface labeling of Escherichia coli via copper(I)-catalyzed [3+2] cycloaddition

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae

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7 January 2021

Chemical strategies for functional proteomics

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7 January 2021

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

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7 January 2021

DNA sequencing with chain-terminating inhibitors

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Click chemistry to construct fluorescent oligonucleotides for DNA sequencing

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Detection of specific DNA sequences by fluorescence amplification: a color complementation assay

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Synthesis of 5- and 6-hydroxymethylfluorescein phosphoramidites

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

10.1016/S1359-6446(03)02933-7

Identifiers

DOI

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30 July 2017

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