(Q33963551)

30 July 2017

title

Analysis of ku80-mutant mice and cells with deficient levels of p53 (English)

1 reference

30 July 2017

D S Lim

1

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30 July 2017

H Vogel

2

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30 July 2017

D M Willerford

3

1 reference

30 July 2017

A T Sands

4

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30 July 2017

K A Platt

5

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30 July 2017

P Hasty

6

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30 July 2017

language of work or name

English

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publication date

1 June 2000

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Molecular and Cellular Biology

30 July 2017

published in

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30 July 2017

volume

20

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30 July 2017

issue

11

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30 July 2017

page(s)

3772-3780

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

30 July 2017

cites work

1 reference

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The effects of streptonigrin on cultured human leukocytes

5 July 2018

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Aging: a theory based on free radical and radiation chemistry

5 July 2018

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Deletion of Ku86 causes early onset of senescence in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

5 July 2018

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The DNA-dependent protein kinase

5 July 2018

1 reference

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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

5 July 2018

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

5 July 2018

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Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system

5 July 2018

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Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Aging and cancer: the double-edged sword of replicative senescence

5 July 2018

1 reference

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Cell cycle checkpoints: preventing an identity crisis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Chromosomal double-strand break repair in Ku80-deficient cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

5 July 2018

p53: puzzle and paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

5 July 2018

1 reference

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Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

Colony size distributions as a measure of in vivo and in vitro aging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85695

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes

29 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805721

12 December 2020

V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805721

12 December 2020

Mechanism of interaction between Ku protein and DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805721

12 December 2020

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805721

12 December 2020

The scid mutation in mice causes a general defect in DNA repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805721

12 December 2020

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805721

12 December 2020

Rapid allelotype analysis of p53 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10805721

12 December 2020

10.1128/MCB.20.11.3772-3780.2000

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference