(Q33849349)

29 July 2017

title

Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress (English)

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29 July 2017

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S Li

1

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29 July 2017

B P Chen

2

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29 July 2017

N Azuma

3

1 reference

29 July 2017

Y L Hu

4

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29 July 2017

S Z Wu

5

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29 July 2017

B E Sumpio

6

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29 July 2017

J Y Shyy

7

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29 July 2017

S Chien

8

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29 July 2017

language of work or name

English

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publication date

1 April 1999

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Journal of Clinical Investigation

29 July 2017

published in

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29 July 2017

volume

103

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29 July 2017

issue

8

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29 July 2017

page(s)

1141-1150

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

29 July 2017

cites work

1 reference

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Integrin-mediated signals regulated by members of the rho family of GTPases

5 July 2018

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Effects of mechanical forces on signal transduction and gene expression in endothelial cells

5 July 2018

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Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases

5 July 2018

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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

5 July 2018

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Rho GTPases and signaling networks

5 July 2018

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A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion

5 July 2018

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p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions

5 July 2018

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Translocation of rhoA associated with Ca2+ sensitization of smooth muscle

5 July 2018

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Effects of oxygen tension and shear stress on human endothelial cell prostacyclin production

5 July 2018

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Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gbeta/gamma-dependent signaling pathways

5 July 2018

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Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

5 July 2018

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Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor

5 July 2018

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The Ras-JNK pathway is involved in shear-induced gene expression

5 July 2018

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Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion

5 July 2018

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Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin.

5 July 2018

1 reference

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Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress.

5 July 2018

1 reference

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Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase.

5 July 2018

1 reference

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Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

5 July 2018

1 reference

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Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

5 July 2018

1 reference

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Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

5 July 2018

1 reference

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An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Pulsatile and steady flow induces c-fos expression in human endothelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

The role of fluid mechanics in the localization and detection of atherosclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Quantitative studies of endothelial cell adhesion. Directional remodeling of focal adhesion sites in response to flow forces

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Flow-mediated endothelial mechanotransduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

The elongation and orientation of cultured endothelial cells in response to shear stress.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

An essential role of myosin light-chain kinase in the regulation of agonist- and fluid flow-stimulated Ca2+ influx in endothelial cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Effect of differential shear stress on platelet aggregation, surface thrombosis, and endothelialization of bilateral carotid-femoral grafts in the dog.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408275

Bacterial toxins block endothelial wound repair. Evidence that Rho GTPases control cytoskeletal rearrangements in migrating endothelial cells

29 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

Endothelial regneration. I. Quantitative analysis of initial stages of endothelial regeneration in rat aortic intima

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

Flow effects on prostacyclin production by cultured human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

In vivo modulation of endothelial F-actin microfilaments by experimental alterations in shear stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

Endothelial cell signaling and cytoskeletal changes in response to shear stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

Shear stress modulates endothelial cell morphology and F-actin organization through the regulation of focal adhesion-associated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

Human aortic endothelial cell migration onto stent surfaces under static and flow conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes. Apparent involvement of phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

ATP-independent membrane depolarization with ischemia in the oxygen-ventilated isolated rat lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/10207166

12 December 2020

Identifiers

DOI

10.1172/JCI5367

1 reference

29 July 2017

1 reference

29 July 2017

1 reference