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Apoptosis in cancer

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Europe PubMed Central

Apoptosis in cancer (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

apoptotic process

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based on heuristic

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author name string

Lowe SW

1

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Europe PubMed Central

PubMed publication ID

29 July 2017

Lin AW

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

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publication date

1 March 2000

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Europe PubMed Central

PubMed publication ID

29 July 2017

21

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Europe PubMed Central

PubMed publication ID

29 July 2017

3

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Europe PubMed Central

PubMed publication ID

29 July 2017

485-495

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Europe PubMed Central

PubMed publication ID

29 July 2017

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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Cell death: the significance of apoptosis

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21 January 2018

Apoptosis. Its significance in cancer and cancer therapy

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21 January 2018

Apoptosis in the pathogenesis and treatment of disease

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Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

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21 January 2018

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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21 January 2018

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

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21 January 2018

BCL-2 family members and the mitochondria in apoptosis

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21 January 2018

Bcl-2 family proteins

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21 January 2018

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

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21 January 2018

Clinical implications of p53 mutations

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21 January 2018

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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21 January 2018

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

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21 January 2018

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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21 January 2018

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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21 January 2018

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice.

1 reference

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21 January 2018

The role of p53 in tumour suppression: lessons from mouse models

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21 January 2018

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1 reference

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21 January 2018

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

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21 January 2018

Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

1 reference

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21 January 2018

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1 reference

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21 January 2018

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

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21 January 2018

Inhibitors of cyclin-dependent kinase and cancer

1 reference

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21 January 2018

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

1 reference

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21 January 2018

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

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21 January 2018

Social controls on cell survival and cell death

1 reference

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21 January 2018

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

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21 January 2018

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1 reference

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21 January 2018

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

1 reference

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21 January 2018

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

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21 January 2018

Disruption of epithelial cell-matrix interactions induces apoptosis

1 reference

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21 January 2018

Integrin signaling

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Death receptors: signaling and modulation

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Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins

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FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

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21 January 2018

Mitochondria and apoptosis

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21 January 2018

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

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21 January 2018

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

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21 January 2018

Caspases: enemies within

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Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

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An induced proximity model for caspase-8 activation.

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Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

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BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

1 reference

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21 January 2018

Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

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21 January 2018

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

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21 January 2018

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

1 reference

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21 January 2018

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

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21 January 2018

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

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Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activity

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21 January 2018

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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Regulation of cell death protease caspase-9 by phosphorylation

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21 January 2018

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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21 January 2018

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

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21 January 2018

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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BID: a novel BH3 domain-only death agonist

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21 January 2018

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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21 January 2018

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1 reference

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21 January 2018

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

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21 January 2018

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

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21 January 2018

Apoptotic cell death induced by c-myc is inhibited by bcl-2.

1 reference

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21 January 2018

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1 reference

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21 January 2018

Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins

1 reference

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21 January 2018

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

1 reference

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21 January 2018

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

1 reference

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21 January 2018

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

1 reference

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21 January 2018

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

1 reference

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21 January 2018

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Mediation of c-Myc-induced apoptosis by p53.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

1 reference

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21 January 2018

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

c-Myc target genes involved in cell growth, apoptosis, and metabolism

1 reference

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21 January 2018

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

E1A signaling to p53 involves the p19(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Oncogene-dependent apoptosis in extracts from drug-resistant cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Bax directly induces release of cytochrome c from isolated mitochondria

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

A model for p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Oncogene-dependent apoptosis is mediated by caspase-9.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells

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21 January 2018

Drug-target interactions: only the first step in the commitment to a programmed cell death?

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21 January 2018

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Senescence of human fibroblasts induced by oncogenic Raf.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Inactivation of Bcl-2 by phosphorylation

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Therapeutic intervention and signaling

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Ras-GTPase activating protein inhibition specifically induces apoptosis of tumour cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Adenovirus-mediated p53 gene delivery potentiates the radiation-induced growth inhibition of experimental brain tumors

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Adenovirus genes that modulate the sensitivity of virus-infected cells to lysis by TNF.

1 reference

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21 January 2018

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

1 reference

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21 January 2018

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Apoptin specifically causes apoptosis in tumor cells and after UV-treatment in untransformed cells from cancer-prone individuals: a review

1 reference

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21 January 2018

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1 reference

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21 January 2018

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

1 reference

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21 January 2018

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Sunburn and p53 in the onset of skin cancer

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.485

21 January 2018

Identifiers

10.1093/CARCIN/21.3.485

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

0 references

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