(Q33838965)

29 July 2017

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title

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration (English)

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29 July 2017

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Gibson GE

1

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29 July 2017

Park LC

2

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29 July 2017

Sheu KF

3

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29 July 2017

Blass JP

4

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29 July 2017

Calingasan NY

5

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29 July 2017

publication date

1 February 2000

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Neurochemistry International

29 July 2017

published in

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29 July 2017

volume

36

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29 July 2017

issue

2

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29 July 2017

page(s)

97-112

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Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex

29 July 2017

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Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

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Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome

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Distribution of the alpha-ketoglutarate dehydrogenase complex in rat brain

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Selective enrichment of cholinergic neurons with the alpha-ketoglutarate dehydrogenase complex in rat brain

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Blood-Brain Barrier Abnormalities in Vulnerable Brain Regions during Thiamine Deficiency

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Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism

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Oxidative stress is associated with region-specific neuronal death during thiamine deficiency

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Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: inhibition of alpha-ketoglutarate dehydrogenase

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Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length

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Inhibition of α-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly-Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions

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Neurofibrillary tangles in chronic alcoholics.

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7 January 2021

On the role of the calcium transport cycle in heart and other mammalian mitochondria

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7 January 2021

Ca2+ as a second messenger within mitochondria of the heart and other tissues

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7 January 2021

The structure of the human dihydrolipoamide dehydrogenase gene (DLD) and its upstream elements

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7 January 2021

Effect of age on behavioral and enzymatic changes during thiamin deficiency

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7 January 2021

Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs

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7 January 2021

Inhibition of acetylcholine synthesis and of carbohydrate utilization by maple-syrup-urine disease metabolites

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7 January 2021

The role of the cholinergic system in thiamin deficiency

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7 January 2021

Correlation of enzymatic, metabolic, and behavioral deficits in thiamin deficiency and its reversal

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7 January 2021

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

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7 January 2021

Regionally selective alterations in enzymatic activities and metabolic fluxes during thiamin deficiency

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7 January 2021

Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation.

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7 January 2021

Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation

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7 January 2021

Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits

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7 January 2021

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

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7 January 2021

Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation

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7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

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7 January 2021

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

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7 January 2021

Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons

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7 January 2021

Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy

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7 January 2021

Deficiency of dihydrolipoamide dehydrogenase due to two mutant alleles (E340K and G101del). Analysis of a family and prenatal testing

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7 January 2021

Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal

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7 January 2021

Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP.

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7 January 2021

Characterization of the transcriptional regulatory region of the human dihydrolipoamide dehydrogenase gene

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7 January 2021

Targeted disruption of the murine dihydrolipoamide dehydrogenase gene (Dld) results in perigastrulation lethality

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7 January 2021

Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).

1 reference

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7 January 2021

Observations upon carbohydrate metabolism in birds: The relation between the lactic acid content of the brain and the symptoms of opisthotonus in rice-fed pigeons

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2899%2900114-X

7 January 2021

Association between the gene encoding the E2 subunit of the alpha-ketoglutarate dehydrogenase complex and Parkinson's disease

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7 January 2021

The hereditary ataxias

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7 January 2021

A familial progressive neurodegenerative disease with 2-oxoglutaric aciduria

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7 January 2021

Cloning, structure, chromosomal localization and promoter analysis of human 2-oxoglutarate dehydrogenase gene

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7 January 2021

Cloning and nucleotide sequence of the cDNA encoding human 2-oxoglutarate dehydrogenase (lipoamide)

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7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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7 January 2021

The acute neurotoxic effect of beta-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F.

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7 January 2021

Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors

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7 January 2021

Neurotoxicity of ammonia and fatty acids: differential inhibition of mitochondrial dehydrogenases by ammonia and fatty acyl coenzyme A derivatives

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7 January 2021

Effect of micromolar Ca2+ on NADH inhibition of bovine kidney alpha-ketoglutarate dehydrogenase complex and possible role of Ca2+ in signal amplification

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7 January 2021

Regulation of bovine kidney alpha-ketoglutarate dehydrogenase complex by calcium ion and adenine nucleotides. Effects on S0.5 for alpha-ketoglutarate

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7 January 2021

Inhibition of bovine kidney alpha-ketoglutarate dehydrogenase complex by reduced nicotinamide adenine dinucleotide in the presence or absence of calcium ion and effect of adenosine 5'-diphosphate on reduced nicotinamide adenine dinucleotide inhibiti

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7 January 2021

Inactivation of beef brain alpha-ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites. Possible mechanism of anticonvulsant and toxic actions

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7 January 2021

Parallel measurement of oxoglutarate dehydrogenase activity and matrix free Ca2+ in fura-2-loaded heart mitochondria

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7 January 2021

Autoantibodies and antigens in liver diseases--updated

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7 January 2021

Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease.

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7 January 2021

Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease

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7 January 2021

Cerebellar alpha-ketoglutarate dehydrogenase activity is reduced in spinocerebellar ataxia type 1.

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7 January 2021

Brain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease

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7 January 2021

Immunoreactive levels of alpha-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1.

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7 January 2021

Subunit Interactions in the Mammalian -Ketoglutarate Dehydrogenase Complex: EVIDENCE FOR DIRECT ASSOCIATION OF THE -KETOGLUTARATE DEHYDROGENASE AND DIHYDROLIPOAMIDE DEHYDROGENASE COMPONENTS

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7 January 2021

Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration

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7 January 2021

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive dehydrogenases within intact rat-kidney mitochondria

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7 January 2021

Studies on mitochondrial Ca2+-transport and matrix Ca2+ using fura-2-loaded rat heart mitochondria

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7 January 2021

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

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7 January 2021

Inhibition of α-Ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

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7 January 2021

Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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7 January 2021

Thiamine therapy in Alzheimer's disease

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7 January 2021

Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease

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7 January 2021

An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease

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7 January 2021

Role of mitochondria in the etiology and pathogenesis of Parkinson's disease

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7 January 2021

Frequency of IgG and IgM autoantibodies to four specific M2 mitochondrial autoantigens in primary biliary cirrhosis.

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7 January 2021

Alzheimer's disease and DLST genotype.

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7 January 2021

A trial of thiamine in Alzheimer's disease

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7 January 2021

Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia

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7 January 2021

Thiamine pyrophosphate-dependent and thiamine metabolizing enzymes in the deafferented cerebellum and in the intact cerebral cortex of rat.

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7 January 2021

Thiamine deficiency decreases steady-state transketolase and pyruvate dehydrogenase but not alpha-ketoglutarate dehydrogenase mRNA levels in three human cell types

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7 January 2021

Visualization of NMDA receptor-induced mitochondrial calcium accumulation in striatal neurons

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7 January 2021

Domains, motifs, and linkers in 2-oxo acid dehydrogenase multienzyme complexes: a paradigm in the design of a multifunctional protein

1 reference

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7 January 2021

Free radicals in the neurotoxic actions of beta-amyloid

1 reference

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7 January 2021

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity

1 reference

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7 January 2021

Hyperoxia-induced clonogenic killing of HeLa cells associated with respiratory failure and selective inactivation of Krebs cycle enzymes

1 reference

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7 January 2021

Characterization of oxygen-resistant Chinese hamster ovary cells. III. Relative resistance of succinate and alpha-ketoglutarate dehydrogenases to hyperoxic inactivation

1 reference

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7 January 2021

The isomers of thioctic acid alter C-deoxyglucose incorporation in rat basal ganglia

1 reference

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7 January 2021

Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease

1 reference

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7 January 2021

Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain.

1 reference

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7 January 2021

Modulation byDLST of the genetic risk of Alzheimer's disease in a very elderly population

1 reference

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7 January 2021

Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2899%2900114-X

7 January 2021

Calcium-mediated cell injury and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2899%2900114-X

7 January 2021

Presenilins and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2899%2900114-X

7 January 2021

Antibodies against mitochondrial dehydrogenase complexes in primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2899%2900114-X

7 January 2021

10.1016/S0197-0186(99)00114-X

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DOI

1 reference

29 July 2017

1 reference