(Q30450420)

English

The dihydrofolate reductase amplicons in different methotrexate-resistant Chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure

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Europe PubMed Central

PMC publication ID

16 August 2017

The dihydrofolate reductase amplicons in different methotrexate-resistant Chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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author name string

Looney JE

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Ma C

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Leu TH

3

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Flintoff WF

4

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Troutman WB

5

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Europe PubMed Central

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16 August 2017

Hamlin JL

6

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Europe PubMed Central

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16 August 2017

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publication date

1 December 1988

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Europe PubMed Central

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16 August 2017

Molecular and Cellular Biology

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Europe PubMed Central

PMC publication ID

16 August 2017

8

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Europe PubMed Central

PMC publication ID

16 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

5268-5279

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Moderate-level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

DNA sequence amplification in mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Gene amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Gene amplification in cultured animal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Amplification of a cloned Chinese hamster dihydrofolate reductase gene after transfer into a dihydrofolate reductase-deficient cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Cloning of the initiation region of a mammalian chromosomal replicon.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Gene amplification in methotrexate-resistant mouse cells. IV. Different DNA sequences are amplified in different resistant lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Overproduction of Dihydrofolate Reductase and Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Single-Copy and Amplified CAD Genes in Syrian Hamster Chromosomes Localized by a Highly Sensitive Method for In Situ Hybridization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Isolation of high-molecular-weight DNA from mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Rapid transfer of DNA from agarose gels to nylon membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Isolation of the amplified dihydrofolate reductase domain from methotrexate-resistant Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Segregation and rearrangement of coamplified genes in different lineages of mutant cells that overproduce adenylate deaminase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

A hotspot for novel amplification joints in a mosaic of Alu-like repeats and palindromic A + T-rich DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Structure of DNA formed in the first step of CAD gene amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Amplification units containing human N-myc and c-myc genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Similar 150-kilobase DNA sequences are amplified in independently derived methotrexate-resistant Chinese hamster cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Large inverted duplications are associated with gene amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Organization and genesis of dihydrofolate reductase amplicons in the genome of a methotrexate-resistant Chinese hamster ovary cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Eucaryotic DNA: organization of the genome for replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

20 June 2018

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=365629

26 November 2018

Replication pattern of a large homogenously staining chromosome region in antifolate-resistant Chinese hamster cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/3244355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene amplification in methotrexate-resistant mouse cells. III. Interrelationships between chromosome changes and DNA sequence amplification or loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/3244355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cellular oncogene (c-Ki-ras) is amplified, overexpressed and located within karyotypic abnormalities in mouse adrenocortical tumour cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/3244355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification

1 reference

https://pubmed.ncbi.nlm.nih.gov/3244355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fractionation of large mammalian DNA restriction fragments using vertical pulsed-field gradient gel electrophoresis

1 reference

https://pubmed.ncbi.nlm.nih.gov/3244355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.8.12.5268

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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