(Q30444700)

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23 December 2019

title

Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17190815%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

Vanesa Fernández Majada

1

1 reference

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23 December 2019

Felip Vilardell

4

1 reference

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23 December 2019

Àlex Robert-Moreno

5

1 reference

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23 December 2019

Alvaro Aytes

6

1 reference

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23 December 2019

Gabriel Capella

8

1 reference

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23 December 2019

Anna Bigas Salvans

11

1 reference

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23 December 2019

author name string

C Aguilera

2

1 reference

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23 December 2019

A Villanueva

3

1 reference

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23 December 2019

F X Real

7

1 reference

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23 December 2019

M W Mayo

9

1 reference

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23 December 2019

L Espinosa

10

1 reference

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23 December 2019

language of work or name

English

0 references

publication date

26 December 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17190815%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

23 December 2019

published in

1 reference

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23 December 2019

volume

104

1 reference

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23 December 2019

issue

1

1 reference

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23 December 2019

page(s)

276-281

1 reference

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Nuclear factor-kappaB in cancer development and progression

23 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Recent insights into the role of Notch signaling in tumorigenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Meningioma transcript profiles reveal deregulated Notch signaling pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Alteration of SMRT tumor suppressor function in transformed non-Hodgkin lymphomas

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

N-CoR controls differentiation of neural stem cells into astrocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Biological roles and mechanistic actions of co-repressor complexes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

HERP, a new primary target of Notch regulated by ligand binding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Control of endodermal endocrine development by Hes-1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Aberrant rel/nfkb genes and activity in human cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

The bHLH gene Hes1 is essential for expansion of early T cell precursors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

The multistep nature of cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Signalling downstream of activated mammalian Notch

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Helix-loop-helix genes translocated in lymphoid leukemia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606476104

A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606476104

IkappaB kinase alpha and p65/RelA contribute to optimal epidermal growth factor-induced c-fos gene expression independent of IkappaBalpha degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606476104

Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1765449

Notch signals control the fate of immature progenitor cells in the intestine

26 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0606476104

The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/17190815

12 December 2020

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17190815

12 December 2020

Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17190815

12 December 2020

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17190815

12 December 2020

Identifiers

DOI

10.1073/PNAS.0606476104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17190815%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17190815%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

PubMed publication ID

17190815

1 reference